Table 1—

Baseline characteristics and effects of EPA on metabolic parameters, lipoprotein profiles, and CRP

Control
EPA
Before3 monthsBefore3 months
BMI (kg/m2)29.2 ± 0.9129.1 ± 0.9231.0 ± 1.2230.8 ± 1.26
EPA (μg/ml)79.2 ± 17.864.6 ± 11.6*77.2 ± 11.5125 ± 12.3
Arachidonic acid (μg/ml)145 ± 12.1148 ± 8.08165 ± 7.34152 ± 9.72
EPA/arachidonic acid0.52 ± 0.100.44 ± 0.08*0.48 ± 0.070.88 ± 0.11
FPG (mmol/l)6.88 ± 0.477.16 ± 0.626.16 ± 0.576.00 ± 0.52
A1C (%)6.57 ± 0.256.47 ± 0.266.11 ± 0.206.02 ± 0.24
Insulin concentration (pmol/l)101 ± 14.5100 ± 12.0104 ± 23.195.4 ± 15.1
Total cholesterol (mmol/l)5.38 ± 0.215.30 ± 0.245.46 ± 0.195.15 ± 0.16
LDL cholesterol (mmol/l)3.18 ± 0.162.97 ± 0.193.44 ± 0.153.18 ± 0.15
HDL cholesterol (mmol/l)1.46 ± 0.071.38 ± 0.111.42 ± 0.081.39 ± 0.07
Triglyceride (mmol/l)1.89 ± 0.191.62 ± 0.211.93 ± 0.201.57 ± 0.11
RLP cholesterol (mmol/l)0.19 ± 0.020.16 ± 0.030.19 ± 0.020.15 ± 0.01
RLP triglyceride (mmol/l)0.44 ± 0.060.58 ± 0.160.43 ± 0.090.26 ± 0.02*§
CETP activity (nmol · ml−1 · h−1)203 ± 1.47202 ± 2.26205 ± 3.05200 ± 1.75*
sdLDL (mmol/l)0.26 ± 0.080.23 ± 0.080.23 ± 0.040.18 ± 0.04
sdLDL proportion (%)7.33 ± 2.186.82 ± 2.366.78 ± 1.285.51 ± 1.09
CRP (mg/dl)0.11 ± 0.030.10 ± 0.030.22 ± 0.080.08 ± 0.02*
  • Data are means ± SE.

  • *

    * P < 0.05,

  • P < 0.01 vs. before determined by two-tailed, paired t test.

  • P < 0.01,

  • §

    § P < 0.05 vs. control determined by Student’s t test. FPG, fasting plasma glucose.