Table 1—

Insulin secretory response during hyperglycemic clamp

Baseline
End point
Mean change
PlaceboOlanzapineRisperidonePlaceboOlanzapineRisperidonePlaceboOlanzapineRisperidone
Insulin AUC0–10 (pmol · l−1 · min)92.6 (81.7)118.7 (110.2)80.4 (39.6)89.3 (76.2)162.7 (162.1)103.3 (53.1)−3.3 (10.6)44.0 (10.9)*22.9 (12.4)
C-peptide AUC0–10 (pmol · l−1 · min)346.1 (177.4)393.6 (262.3)324.5 (119.7)355.0 (191.4)433.0 (337.0)400.3 (213.5)8.9 (30.7)39.4 (31.6)75.8 (36.1)*
ISIclamp (mg · min−1 · kg−1)/(pmol/l)0.033 (0.028)0.037 (0.027)0.030 (0.015)0.035 (0.024)0.030 (0.026)0.025 (0.019)0.002 (0.003)−0.007 (0.003)*−0.005 (0.004)
DI2.07 (0.85)2.44 (1.12)2.02 (0.81)2.16 (0.77)2.26 (0.87)2.09 (1.16)0.10 (0.17)−0.18 (0.17)0.07 (0.20)
  • Data are ISIclamp and DI values.

  • *

    * P < 0.05 for within-group change from baseline;

  • P < 0.05 compared with placebo.