Table 2—

Mean changes in metabolic and pain parameters in pooled DPNP studies

Acute studies
Extension studies
DuloxetinePlaceboPDuloxetineRoutine careP
n685339580287
FPG (mmol/l)0.50−0.110.0640.67−0.64<0.001
A1C (%)−0.09−0.070.7660.520.19<0.001
Triglycerides (mmol/l)−0.190.070.1060.050.000.854
LDL cholesterol (mmol/l)0.08−0.020.0750.02−0.090.068
HDL cholesterol (mmol/l)0.030.000.008−0.01−0.080.002
Total cholesterol (mmol/l)0.07−0.030.0900.06−0.160.005
Weight (kg)−1.030.03<0.0010.310.490.531
Pain severity (0–10 scale)−2.70−1.64<0.001NANA