Table 1—

Baseline BMI, waist circumference, and RR of type 2 diabetes in the Nurses’ Health Study from 1986 through 2002

BMI (kg/m2) (n = 68,907)
<2121–22.923–24.925–26.927–29.930–32.933–34.935–39.940P for trend
n95224438555944730328482234
Person-years (1,034,808 )165,274229,913224,553150,502137,71467,44322,61526,27710,567
Age-adjusted RR (95% CI)1.001.68 (1.32–2.13)3.32 (2.66–4.14)6.26 (5.04–7.79)11.67 (9.45–14.41)18.62 (15.04–23.07)25.31 (20.14–31.81)32.56 (26.12–40.57)40.28 (31.73–51.13)<0.001
Multivariate RR (95% CI)*1.001.65 (1.30–2.10)3.10 (2.48–3.87)5.51 (4.43–6.86)9.80 (7.93–12.11)14.83 (11.96–18.39)19.11 (15.19–24.06)23.98 (19.21–29.95)27.96 (21.97–35.58)<0.001
Waist circumference (inches) (n = 43,986)
20–2828–29.930–31.932–34.9≥35P for trend
n581562485841,096
Person-years (664,976 )149,922156,197125,540131,638101,633
Age-adjusted RR (95% CI)1.002.55 (1.89–3.45)5.03 (3.78–6.69)11.25 (8.58–14.75)27.69 (21.24–36.09)<0.001
Multivariate RR (95% CI)*1.002.48 (1.83–3.35)4.62 (3.47–6.15)9.51 (7.25–12.47)21.44 (16.42–28.00)<0.001
  • *

    * Adjusted for age (<49, 50–54, 55–59, 60–64, and 65 years), smoking status (never, past, or current [1–14, 15–24, or 25 cigarettes/day]), family history of diabetes, postmenopausal status and hormone use (pre- and postmenopausal status and hormone use as never, past, or current), physical activity (quintiles), and alcohol consumption (0, 0.1–4.9, 5–14.9, or 15 g/day).