Table 2—

Crude and adjusted geometric means (95% CI) of sex steroid hormone concentrations in men aged ≥20 years by diabetes status, U.S. 1988–1994

Crude geometric mean (95% CI)
Adjusted geometric mean (95% CI)*
OverallNo diabetesDiabetesOverallNo diabetesDiabetes
n1,4131,3121011,4131,312101
Total testosterone (ng/ml)5.11 (4.93–5.29)5.15 (4.97–5.34)4.12 (3.78–4.49)5.11 (4.94–5.28)5.12 (4.95–5.30)4.72 (4.31–5.18)
Estradiol (E2) (pg/ml)35.68 (34.27–37.15)35.67 (34.22–37.18)35.93 (33.03–39.09)35.68 (34.31–37.11)35.64 (34.24–37.10)36.73 (33.46–40.32)
SHBG (nmol/l)35.12 (33.59–36.72)34.97 (33.41–36.62)38.92 (35.45–42.73)35.12 (33.79–36.50)35.18 (33.84–36.57)33.68 (30.41–37.31)
AAG (ng/ml)12.02 (11.44–12..63)12.12 (11.52–12.76)9.78 (8.87–10.78)12.08 (11.48–12.58)12.04 (11.50–12.61)11.46 (9.97–13.18)
Estimated free testosterone (ng/ml)0.10 (0.10–0.11)0.10 (0.10–0.11)0.07 (0.07–0.08)0.10 (0.10–0.10)0.10 (0.10–0.11)0.10 (0.09–0.11)
Estimated bioavailable testosterone (ng/ml)2.38 (2.28–2.49)2.41 (2.31–2.52)1.74 (1.57–1.93)2.38 (2.31–2.46)2.39 (2.31–2.47)2.24 (2.02–2.47)
Estradiol:total testosterone (1,000)*7.40 (7.01–7.81)7.33 (6.94–7.74)9.24 (8.17–10.44)7.40 (7.01–7.80)7.36 (6.98–7.77)8.23 (7.35–9.22)
Total testosterone:SHBG0.50 (0.48–0.53)0.51 (0.49–0.54)0.37 (0.33–0.41)0.50 (0.49–0.52)0.50 (0.49–0.52)0.49 (0.43–0.55)
Estradiol:SHBG (1,000)*3.73 (3.47–4.01)3.74 (3.48–4.03)3.39 (3.11–3.69)3.73 (3.49–3.99)3.72 (3.48–3.98)4.00 (3.50–4.59)
  • *

    * Adjusted for age and race/ethnicity.