Table 3—

Adjusted* OR (95% CI) of diabetes by tertiles of sex steroid hormone concentrations, NHANES III

Q1 (lowest)Q2Q3 (highest)P trend
Total testosterone (≤4.54, 4.55–6.27, >6.27 ng/ml)1.27 (0.61–2.65)0.51 (0.15–1.72)1.00 (reference)0.27
Estradiol (E2) (≤31.90, 31.91–40.26, >40.26 pg/ml)0.88 (0.36–2.18)0.96 (0.36–2.57)1.00 (reference)0.79
SHBG (≤28.03, 28.04–43.50, >43.50 nmol/l)0.68 (0.29–1.59)0.90 (0.43–1.87)1.00 (reference)0.42
AAG (≤9.57, 9.58–15.44, >15.44 ng/ml)2.10 (0.79–5.58)1.69 (0.64–4.46)1.00 (reference)0.12
Estimated free testosterone (≤0.09, 0.10–0.14, >0.14 ng/ml)4.12 (1.25–13.55)2.86 (0.78–10.45)1.00 (reference)0.04
Estimated bioavailable testosterone (≤2.11, 2.12–3.02, >3.02 ng/ml)3.93 (1.39–11.13)3.05 (0.85–10.88)1.00 (reference)0.01
Estradiol:total testosterone (1,000) (≤6.24, 6.25–8.23, >8.23)*0.90 (0.43–1.89)0.99 (0.43–2.26)1.00 (reference)0.82
Total testosterone:SHBG (≤0.45, 0.46–0.63, >0.63)2.19 (0.83–5.73)1.65 (0.71–3.83)1.00 (reference)0.11
Estradiol:SHBG (1,000) (≤2.92, 2.93–4.75, >4.75)*2.10 (0.79–5.58)1.50 (0.61–3.65)1.00 (reference)0.14
  • *

    * Adjusted for age, race/ethnicity, BMI, and waist-to-hip ratio.