Table 1—

Baseline clinical characteristics, symptoms, and signs and type of Candida species in the ITT and PP groups

ParametersITT analysis
P valuePP analysis
P value
FluconazoleBoric acidFluconazoleBoric acid
n55564950
Age (years)40.2 ± 10.741.2 ± 11.30.6340.2 ± 9.840.8 ± 11.50.78
BMI (kg/m2)24.4 ± 5.424.9 ± 4.50.6424.6 ± 5.624.7 ± 4.70.88
A1C (%)9.36 ± 2.58.5 ± 1.60.049.35 ± 2.88.5 ± 1.70.05
Postmenopausal21 (38.1)17 (30.3)0.5019 (38.8)14 (28.0)0.35
Use of commercial sanitary napkins during menstruation14 (41.2)22 (56.4)0.2813 (43.3)22 (61.1)0.23
VVC symptoms for >1 month50 (90.9)47 (83.9)0.4144 (89.8)41 (82.0)0.40
Vulval pruritus45 (81.8)41 (73.2)0.3940 (81.6)35 (70.0)0.26
Vulval edema5 (9.0)13 (23.2)0.085 (10.2)9 (18.0)0.40
Vaginal congestion39 (70.9)43 (76.7)0.6233 (67.3)37 (74.0)0.61
Direct microscopy positivity35 (63.6)30 (53.5)0.3729 (59.2)24 (48.0)0.36
C. glabrata35 (63.6)33 (58.9)0.7530 (61.2)29 (58.0)0.90
C. albicans14 (25.4)18 (32.1)0.9513 (26.5)16 (32.0)0.92
Other Candida species6 (10.9)5 (8.9)0.976 (12.2)5 (10.0)0.97
  • Data are means ± SD for age, BMI, and A1C and n (%) for other indices in the two treatment arms in ITT and PP groups. P values test differences in the means or proportions observed in the two treatment arms.