Table 1—

Clinical symptoms, hormonal parameters, measures of insulin resistance, lipid profiles, and arterial function over 6 months

Group 1: metformin (n = 36)
Group 2: high-dose OCP (n = 31)
Group 3: low-dose OCP/spironolactone (n = 33)
Baseline6 monthsMean change (95% CI)Baseline6 monthsMean change (95% CI)Baseline6 monthsMean change (95% CI)
Systolic blood pressure (mmHg)121118−2.6 (−5.1 to 10.3)1141226.9 (−2.6 to 16.3)115112−2.9 (−4.5 to 10.3)
BMI (kg/m2)36.335.9−0.5 (−2.4 to 4.0)36.536.80.3 (−0.9 to 0.3)35.535.2−0.3 (−0.4 to 0.9)
WHR0.870.890.18 (−0.03 to 0.01)0.840.850.01 (−0.03 to 0.01)0.860.880.02 (−0.01 to 0.04)
Symptoms/androgens
    Menstrual cycle (days)11265*−47.1 (−1.5 to −93)7532*−44 (−18 to −69)10139*−61.8 (−27.3 to −96)
    Ferriman-Gallwey8.806.1*−2.7 (−1.5 to −3.9)6.74.6*−2.0 (−0.9 to −3.2)6.44.3*−2.0 (−0.7 to −3.4)
    Testosterone (nmol/l)2.502.38−0.2 (−0.3 to 0.6)2.101.65*−0.47 (−0.1 to −0.8)2.762.00*−0.7 (−0.4 to −1.2)
    DHEAS (μmol/l)5.495.10−0.37 (−1.0 to 0.2)4.893.53*−1.4 (−0.7 to −2.1)4.293.62*−0.7 (−0.2 to −1.1)
    SHBG (nmol/l)30.137.47.4 (−4.6 to 19.4)33.9148*115 (143 to 87)33.578.5*44.7 (60 to 29)§
    FAI10.38.2−2.1 (−3.1 to 3.2)8.31.5*−6.8 (−9.4 to −4.2)9.83.5*−6.3 (−8.1 to −4.4)
IR
    Fasting insulin (units/l)20.414.5−6.0 (−12.6 to 0.4)20.221.51.15 (−4.2 to 6.5)18.316.6−1.67 (−2.3 to 5.6)
    HOMA4.423.29*−1.13 (−0.6 to −2.8)4.104.160.10 (−1.3 to 1.1)3.703.58−0.22 (−1.14 to 0.7)
    AUC insulin11,9097,878*−4,030 (−1,489 to −6,571)8,9501,1195*2,246 (931 to 3,561)10,80610,779−34 (−1,942 to 2,011)
Lipid profiles (mmol/l)
    Total cholesterol5.285.12−0.17 (−0.4 to 0.1)5.104.99−0.12 (−0.2 to 0.4)5.075.270.19 (−0.1 to 0.5)
    HDL cholesterol1.241.14*−0.1 (−0.03 to −0.2)1.361.460.10 (−0.1 to 0.20)1.221.220.01 (−0.1 to 0.1)
    LDL cholesterol3.373.33−0.04 (−0.2 to 0.3)3.182.78*−0.40 (−0.1 to −0.7)3.213.280.06 (−0.3 to 0.2)§
    Triglycerides1.521.580.06 (−0.4 to 0.23)1.251.66*0.4 (0.1 to 0.7)1.451.570.13 (−0.1 to 0.3)
Arterial markers
    Central PWV (m/s)7.477.46−0.01 (−0.2 to 0.2)7.468.03*0.56 (0.1 to 1.0)7.137.310.18 (−0.1 to 0.4)
FMD (% of change)10.8412.581.66 (−0.4 to 3.7)11.6511.08−0.57 (−1.7 to 2.9)12.7812.44−0.34 (−1.2 to 1.8)
  • Mean change = change from baseline to 6 months ±95% CI. Within-group change,

  • *

    * P < 0.05, comparing 0 and 6 months. Between groups, P < 0.05.

  • Comparison between groups 1 and 2,

  • comparison between groups 1 and 3,

  • §

    § comparison between group 2 and 3.