Table 1—

Evolution over time of demographics, insulin sensitivity, β-cell function, glucose tolerance, and cardiovascular risk factors in 33 first-degree relatives (24 women and 9 men) of subjects with type 2 diabetes

First assessmentSecond assessmentP value
Age (years)37.9 ± 12.145.2 ± 11.8<0.0001
Weight (kg)84.7 ± 15.192.3 ± 20.20.0008
BMI (kg/m2)28.6 ± 4.431.4 ± 6.40.0003
Waist circumference (cm)100 ± 11105 ± 150.04
Hip circumference (cm)110 ± 7110 ± 90.23
Waist-to-hip ratio0.91 ± 0.080.95 ± 0.090.0003
Fasting glucose (mmol/l)5.14 ± 0.475.25 ± 0.470.51
Fasting insulin (pmol/l)76.6 ± 43.576.4 ± 52.60.99
Adiponectin (μg/ml)13.2 ± 1.112.1 ± 1.10.24
SI (× 10−5 min−1/pmol)4.6 ± 2.7 (3.9)4.3 ± 3.1 (3.0)0.56
AIRg (pmol/l)403 ± 297 (318)338 ± 239 (252)0.08
DI (× 10−5 min−1)1,599 ± 1,094 (1,240)1,253 ± 816 (756)0.02
Sg (× 10−2 min−1)1.83 ± 0.481.70 ± 0.520.22
GEZI (× 10−2 min−1)1.54 ± 0.511.45 ± 0.540.39
Kg (%/min)1.70 ± 0.551.47 ± 0.420.03
2-h glucose (mmol/l)*7.38 ± 1.728.38 ± 2.560.03
AUCG (mmol/l × min)*280 ± 139392 ± 1950.0003
Cholesterol (mg/dl)181 ± 32187 ± 250.006
HDL cholesterol (mg/dl)45 ± 943 ± 100.36
LDL cholesterol (mg/dl)119 ± 27125 ± 230.02
Triglycerides (mg/dl)85 ± 5096 ± 390.048
Systolic blood pressure (mmHg)115 ± 13122 ± 140.005
Diastolic blood pressure (mmHg)72 ± 1175 ± 100.23
  • Data are arithmetic means ± SD with geometric means where appropriate in parentheses. P values are for comparisons between assessments.

  • *

    * Twenty-six subjects had an OGTT at both assessments.