Evolution over time of demographics, insulin sensitivity, β-cell function, and glucose tolerance in subjects with NGT who did or did not progress to IGT
| First assessment | Second assessment | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Nonprogressors | Progressors | P value | Nonprogressors | Progressors | P value | |||||
| n (female/male) | 10 (7/3) | 6 (4/2) | 10 (7/3) | 6 (4/2) | ||||||
| Age (years) | 35.6 ± 7.7 | 39.2 ± 10.9 | 0.59 | 42.1 ± 8.2 | 46.5 ± 10.7 | 0.48 | ||||
| Weight (kg) | 85.5 ± 11.9 | 86.1 ± 20.5 | 0.70 | 89.6 ± 10.0 | 100.8 ± 39.0 | 0.99 | ||||
| BMI (kg/m2) | 27.7 ± 3.2 | 29.3 ± 5.8 | 0.66 | 29.2 ± 2.9 | 34.2 ± 11.4 | 0.23 | ||||
| Waist circumference (cm) | 97 ± 9 | 99 ± 16 | 0.74 | 103 ± 7 | 108 ± 29 | 0.59 | ||||
| Hip circumference (cm) | 111 ± 8 | 111 ± 10 | 0.83 | 109 ± 7 | 115 ± 14 | 0.59 | ||||
| Waist-to-hip ratio | 0.88 ± 0.07 | 0.89 ± 0.11 | 0.45 | 0.95 ± 0.07 | 0.93 ± 0.14 | 0.45 | ||||
| Fasting glucose (mmol/l) | 5.17 ± 0.33 | 5.00 ± 0.28 | 0.36 | 4.94 ± 0.40 | 4.98 ± 0.48 | 0.87 | ||||
| Fasting insulin (pmol/l) | 60.3 ± 19.7 | 60.2 ± 35.6 | 0.45 | 53.3 ± 19.2 | 97.8 ± 71.6 | 0.16 | ||||
| Adiponectin (μg/ml) | 11.9 ± 2.0 | 15.4 ± 3.0 | 0.33 | 10.9 ± 1.5 | 11.4 ± 2.0 | 0.91 | ||||
| SI (× 10−5 min−1/pmol) | 5.8 ± 2.9 (5.2) | 5.1 ± 2.4 (4.6) | 0.55 | 5.6 ± 3.2 (4.8) | 4.5 ± 2.7 (3.7) | 0.42 | ||||
| AIRg (pmol/l) | 509 ± 342 (399) | 355 ± 231 (309) | 0.59 | 452 ± 298 (372) | 267 ± 130 (244) | 0.16 | ||||
| DI (× 10−5 min−1) | 2,437 ± 1,232 (2,075) | 1,646 ± 888 (1,421) | 0.19 | 1,949 ± 824 (1,786) | 1,017 ± 511 (903) | 0.05 | ||||
| Sg (× 10−2 min−1) | 2.27 ± 0.36 | 1.63 ± 0.41 | 0.009 | 2.00 ± 0.57 | 1.53 ± 0.47 | 0.10 | ||||
| GEZI (× 10−2 min−1) | 1.94 ± 0.38 | 1.36 ± 0.49 | 0.051 | 1.73 ± 0.61 | 1.23 ± 0.52 | 0.10 | ||||
| Kg (%/min) | 2.08 ± 0.62 | 1.61 ± 0.45 | 0.08 | 1.73 ± 0.46 | 1.29 ± 0.28 | 0.03 | ||||
| 2-h glucose (mmol/l) | 6.15 ± 0.86 | 6.34 ± 0.61 | 0.87 | 6.12 ± 0.88 | 8.75 ± 1.18 | 0.001 | ||||
| AUCG (mmol/l × min) | 197 ± 69 | 207 ± 66 | 0.74 | 224 ± 76 | 496 ± 101 | 0.001 | ||||
Data are arithmetic means ± SD with geometric means where appropriate in parentheses. P values are for the comparison between progressors and nonprogressors at the same assessment.