Table 2—

Depression and diabetes characteristics of the sample in relation to age subset and maintenance treatment arm

Younger subjects (aged <55 years)
Older subjects (aged ≥55 years)
AllSertralinePlaceboAllSertralinePlacebo
n854738673235
Age of depression onset (years)28.5 ± 12.326.9 ± 12.430.4 ± 12.037.4 ± 19.034.6 ± 15.639.9 ± 21.6
Number of prior episodes of depression5.0 ± 7.75.7 ± 9.74.3 ± 5.14.2 ± 3.85.2 ± 4.63.5 ± 2.9
Family history of depression*39 (54.2)21 (50.0)18 (60.0)26 (44.1)12 (41.4)14 (46.7)
Prior depression treatment*41 (51.9)21 (48.8)20 (55.6)38 (61.3)22 (75.9)16 (48.5)
BDI at baseline21.2 ± 6.921.0 ± 6.921.5 ± 6.922.1 ± 6.522.7 ± 6.721.6 ± 6.3
BDI at randomization4.0 ± 2.64.4 ± 2.93.4 ± 2.14.0 ± 3.24.4 ± 3.33.5 ± 3.1
HDRS at baseline16.2 ± 4.516.3 ± 4.916.0 ± 4.115.3 ± 4.214.8 ± 3.315.8 ± 3.5
HDRS at randomization3.7 ± 3.33.3 ± 2.84.1 ± 3.93.5 ± 2.83.2 ± 2.43.8 ± 3.1
Sertraline dose at recovery (mg/day)118 ± 52120 ± 55116 ± 50116 ± 53116 ± 56117 ± 51
Age of diabetes onset (years)33.7 ± 12.132.8 ± 11.535.0 ± 12.855.1 ± 11.252.7 ± 10.757.3 ± 11.3
Duration of diabetes (years)10.8 ± 9.910.5 ± 9.711.2 ± 10.28.2 ± 8.37.8 ± 8.78.6 ± 8.0
Diabetes complications
    Neuropathy37 (43.5)25 (53.2)12 (31.6)31 (46.3)11 (34.4)20 (57.1)
    Nephropathy10 (11.8)6 (12.8)4 (10.5)6 (9.0)3 (9.4)3 (8.6)
    Retinopathy15 (17.6)9 (19.1)6 (15.8)18 (26.9)10 (31.3)8 (22.9)
    Atherosclerotic8 (9.4)4 (8.5)4 (10.5)14 (20.9)7 (21.9)7 (20.0)
Diabetes management
    Diet only6 (7.1)3 (6.4)3 (7.9)10 (14.9)7 (21.9)3 (8.6)
    Insulin38 (44.7)20 (42.6)18 (47.4)16 (23.9)8 (25.0)8 (22.9)
    Oral agent29 (34.1)18 (38.3)11 (28.9)34 (50.7)14 (43.8)20 (57.1)
    Insulin and oral agent12 (14.1)6 (12.8)6 (15.8)7 (10.4)3 (9.4)4 (11.4)
A1C at baseline (%)8.6 ± 1.88.5 ± 1.88.7 ± 1.77.7 ± 1.57.7 ± 1.57.7 ± 1.6
A1C at randomization (%)8.0 ± 1.78.2 ± 1.87.9 ± 1.67.6 ± 1.47.4 ± 1.17.7 ± 1.7
  • Data are means ± SD or n (%).

  • *

    * Provided for those subjects with available data.

  • P = 0.04 compared with placebo-treated subjects. HDRS, Hamilton Depression Rating Scale.