Depression and diabetes characteristics of the sample in relation to age subset and maintenance treatment arm
| Younger subjects (aged <55 years) | Older subjects (aged ≥55 years) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All | Sertraline | Placebo | All | Sertraline | Placebo | |||||
| n | 85 | 47 | 38 | 67 | 32 | 35 | ||||
| Age of depression onset (years) | 28.5 ± 12.3 | 26.9 ± 12.4 | 30.4 ± 12.0 | 37.4 ± 19.0 | 34.6 ± 15.6 | 39.9 ± 21.6 | ||||
| Number of prior episodes of depression | 5.0 ± 7.7 | 5.7 ± 9.7 | 4.3 ± 5.1 | 4.2 ± 3.8 | 5.2 ± 4.6 | 3.5 ± 2.9 | ||||
| Family history of depression* | 39 (54.2) | 21 (50.0) | 18 (60.0) | 26 (44.1) | 12 (41.4) | 14 (46.7) | ||||
| Prior depression treatment* | 41 (51.9) | 21 (48.8) | 20 (55.6) | 38 (61.3) | 22 (75.9)† | 16 (48.5) | ||||
| BDI at baseline | 21.2 ± 6.9 | 21.0 ± 6.9 | 21.5 ± 6.9 | 22.1 ± 6.5 | 22.7 ± 6.7 | 21.6 ± 6.3 | ||||
| BDI at randomization | 4.0 ± 2.6 | 4.4 ± 2.9 | 3.4 ± 2.1 | 4.0 ± 3.2 | 4.4 ± 3.3 | 3.5 ± 3.1 | ||||
| HDRS at baseline | 16.2 ± 4.5 | 16.3 ± 4.9 | 16.0 ± 4.1 | 15.3 ± 4.2 | 14.8 ± 3.3 | 15.8 ± 3.5 | ||||
| HDRS at randomization | 3.7 ± 3.3 | 3.3 ± 2.8 | 4.1 ± 3.9 | 3.5 ± 2.8 | 3.2 ± 2.4 | 3.8 ± 3.1 | ||||
| Sertraline dose at recovery (mg/day) | 118 ± 52 | 120 ± 55 | 116 ± 50 | 116 ± 53 | 116 ± 56 | 117 ± 51 | ||||
| Age of diabetes onset (years) | 33.7 ± 12.1 | 32.8 ± 11.5 | 35.0 ± 12.8 | 55.1 ± 11.2 | 52.7 ± 10.7 | 57.3 ± 11.3 | ||||
| Duration of diabetes (years) | 10.8 ± 9.9 | 10.5 ± 9.7 | 11.2 ± 10.2 | 8.2 ± 8.3 | 7.8 ± 8.7 | 8.6 ± 8.0 | ||||
| Diabetes complications | ||||||||||
| Neuropathy | 37 (43.5) | 25 (53.2) | 12 (31.6) | 31 (46.3) | 11 (34.4) | 20 (57.1) | ||||
| Nephropathy | 10 (11.8) | 6 (12.8) | 4 (10.5) | 6 (9.0) | 3 (9.4) | 3 (8.6) | ||||
| Retinopathy | 15 (17.6) | 9 (19.1) | 6 (15.8) | 18 (26.9) | 10 (31.3) | 8 (22.9) | ||||
| Atherosclerotic | 8 (9.4) | 4 (8.5) | 4 (10.5) | 14 (20.9) | 7 (21.9) | 7 (20.0) | ||||
| Diabetes management | ||||||||||
| Diet only | 6 (7.1) | 3 (6.4) | 3 (7.9) | 10 (14.9) | 7 (21.9) | 3 (8.6) | ||||
| Insulin | 38 (44.7) | 20 (42.6) | 18 (47.4) | 16 (23.9) | 8 (25.0) | 8 (22.9) | ||||
| Oral agent | 29 (34.1) | 18 (38.3) | 11 (28.9) | 34 (50.7) | 14 (43.8) | 20 (57.1) | ||||
| Insulin and oral agent | 12 (14.1) | 6 (12.8) | 6 (15.8) | 7 (10.4) | 3 (9.4) | 4 (11.4) | ||||
| A1C at baseline (%) | 8.6 ± 1.8 | 8.5 ± 1.8 | 8.7 ± 1.7 | 7.7 ± 1.5 | 7.7 ± 1.5 | 7.7 ± 1.6 | ||||
| A1C at randomization (%) | 8.0 ± 1.7 | 8.2 ± 1.8 | 7.9 ± 1.6 | 7.6 ± 1.4 | 7.4 ± 1.1 | 7.7 ± 1.7 | ||||