Table 1—

Anthropometrics, glucose metabolism, and β-cell–function parameters in severely obese patients with type 2 diabetes pre- and postsurgery and in nondiabetic subjects postsurgery

Diabetic
Nondiabetic
PresurgeryP*PostsurgeryPPostsurgery
Body weight (kg)136 ± 100.0189 ± 4NS87 ± 4
BMI (kg/m2)49.5 ± 2.90.0133.1 ± 2.2NS33.1 ± 2.8
Fat-free mass (kg)80 ± 50.0164 ± 3NS57 ± 5
Fat mass (kg)56 ± 50.0126 ± 3NS30 ± 5
Fasting glucose (mmol/l)7.7 ± 0.90.035.1 ± 0.30.014.0 ± 0.4
A1C (%)8.2 ± 0.60.014.1 ± 0.1
Mean 24-h glucose (mmol/l)7.6 ± 0.80.035.3 ± 0.20.014.7 ± 0.4
M (μmol · min−1 · kgFFM−1)26.4 ± 2.70.0155.2 ± 2.10.0168.7 ± 3.3
Fasting insulin (pmol/l)154 (114)NS79 (65)0.0120 (20)
Mean 24-h insulin (pmol/l)233 (182)NS136 (125)0.00158 (19)
24-h insulin output
    nmol/m2228 (83)0.04158 (76)0.0189 (11)
    nmol608 (214)0.01330 (159)0.01167 (37)
β-cell glucose sensitivity
    pmol/min per m2/mmol/l44 (32)0.03776 (89)NS65 (47)
    pmol · min−1 · mmol/l−199 (78)0.1160 (208)NS122 (98)
Rate sensitivity
    nmol/m2 per mmol/l0.45 (1.61)NS0.01 (0.17)NS0.59 (1.20)
    nmol/mmol/l1.3 (3.9)NS0.01 (0.4)NS1.2 (2.3)
Potentiation factor (day/night)1.19 (0.40)NS0.85 (0.53)0.021.37 (0.57)
  • Data are means ± SE or median (interquartile range) unless otherwise indicated. NS, not significant.

  • *

    * Presurgery versus postsurgery by Wilcoxon signed-rank test;

  • diabetic versus nondiabetic by the Mann-Whitney U test.