Table 2

Systolic and diastolic sitting BP, change from baseline to week 12

Study week/statisticsLX4211Placebo
(N = 60)
75 mg qd
(N = 59)200 mg qd
(N = 60)200 mg bid
(N = 60)400 mg qd
(N = 60)
Sitting systolic BP mmHg change from baseline to week 12
N5760595960
 Mean (SD)−0.1 (12.7)−3.9 (12.1)−4.5 (12.1)−5.7 (12.4)−0.3 (13.6)
P value [1]0.9420.0170.007<0.0010.872
 Least significant mean (SE)0.5 (1.5)−3.2 (1.5)−5.4 (1.5)−5.9 (1.5)−0.5 (1.5)
 Least significant mean difference from placebo (SE)1.1 (2.2)−2.7 (2.1)−4.8 (2.1)−5.4 (2.1)
 95% CI for mean difference from placebo(−3.2, 5.3)(−6.9, 1.5)(−9.0, −0.6)(−9.6, −1.2)
 P value vs. placebo0.6240.2020.0240.012
Sitting diastolic BP mmHg change from baseline to week 12
N5760595960
 Mean (SD)−0.6 (8.8)−2.8 (7.9)−2.2 (7.9)−1.6 (8.9)−0.5 (9.1)
P value [1]0.5980.0070.0350.1640.697
 Least significant mean (SE)−0.2 (1.0)−2.1 (1.0)−2.8 (1.0)−2.0 (1.0)−0.7 (1.0)
 Least significant mean difference from placebo (SE)0.5 (1.4)−1.4 (1.4)−2.2 (1.4)−1.3 (1.4)
 95% CI for mean difference from placebo(−2.4, 3.3)(−4.2, 1.4)(−5.0, 0.6)(−4.1, 1.5)
P value vs. placebo0.7480.3270.1300.355