Sitting systolic BP mmHg change from baseline to week 12 |

*N* | 57 | 60 | 59 | 59 | 60 |

Mean (SD) | −0.1 (12.7) | −3.9 (12.1) | −4.5 (12.1) | −5.7 (12.4) | −0.3 (13.6) |

*P* value [1] | 0.942 | 0.017 | 0.007 | <0.001 | 0.872 |

Least significant mean (SE) | 0.5 (1.5) | −3.2 (1.5) | −5.4 (1.5) | −5.9 (1.5) | −0.5 (1.5) |

Least significant mean difference from placebo (SE) | 1.1 (2.2) | −2.7 (2.1) | −4.8 (2.1) | −5.4 (2.1) | — |

95% CI for mean difference from placebo | (−3.2, 5.3) | (−6.9, 1.5) | (−9.0, −0.6) | (−9.6, −1.2) | — |

* P* value vs. placebo | 0.624 | 0.202 | 0.024 | 0.012 | — |

Sitting diastolic BP mmHg change from baseline to week 12 |

*N* | 57 | 60 | 59 | 59 | 60 |

Mean (SD) | −0.6 (8.8) | −2.8 (7.9) | −2.2 (7.9) | −1.6 (8.9) | −0.5 (9.1) |

*P* value [1] | 0.598 | 0.007 | 0.035 | 0.164 | 0.697 |

Least significant mean (SE) | −0.2 (1.0) | −2.1 (1.0) | −2.8 (1.0) | −2.0 (1.0) | −0.7 (1.0) |

Least significant mean difference from placebo (SE) | 0.5 (1.4) | −1.4 (1.4) | −2.2 (1.4) | −1.3 (1.4) | — |

95% CI for mean difference from placebo | (−2.4, 3.3) | (−4.2, 1.4) | (−5.0, 0.6) | (−4.1, 1.5) | — |

*P* value vs. placebo | 0.748 | 0.327 | 0.130 | 0.355 | — |