Table 3—

ORs and 95% CI in multivariate analysis of factors related to severe hypoglycemia

OR (95% CI)
NephropathyNeuropathyRetinopathy
Sex, male vs. female1.64 (0.75–3.58)1.74 (0.79–3.85)1.47 (0.59–3.67)
Age, 1 year increase1.01 (0.97–1.04)1.01 (0.97–1.04)0.98 (0.95–1.03)
A1C, 1 SD increase0.86 (0.62–1.20)0.85 (0.61–1.19)0.93 (0.64–1.33)
Waist-to-hip ratio, 1 SD increase0.60 (0.40–0.90)*0.59 (0.39–0.89)*0.69 (0.44–1.10)
Orthostatic hypotension, present0.80 (0.32–1.99)0.82 (0.33–2.05)1.05 (0.39–2.83)
Alcohol consumption, 1 SD increase0.99 (0.71–1.41)1.08 (0.76–1.53)1.05 (0.72–1.53)
Smoking
    Past vs. never smoker1.02 (0.50–2.41)0.98 (0.44–2.15)0.93 (0.36–2.39)
    Current vs. never smoker2.65 (1.20–5.82)*2.68 (1.21–5.92)*2.10 (0.90–5.01)
Intensive insulin treatment, present1.21 (0.60–2.43)1.24 (0.62–2.48)1.59 (0.72–3.54)
Past severe hypoglycemia, present2.76 (0.87–8.74)2.59 (0.81–8.28)2.60 (0.71–9.52)
Nephropathy, present1.86 (0.91–3.79)
Neuropathy, present1.88 (0.98–3.60)
Retinopathy
Moderate to severe NPDR vs. none to mild NPDR0.70 (0.25–1.99)
Proliferative vs. none to mild NPDR0.99 (0.44–2.25)
  • *

    * P < 0.05. NPDR, nonproliferative diabetic retinopathy.