Table 2—

Incidence rates and RRs of stroke subtypes by diabetes, the Nurses’ Health Study, 1976–2002

VariablesNo diabetesType 1 diabetesType 2 diabetes
Total stroke
    Cases2,38433637
    Incidence*92475240
    Age-adjusted RR1.05.9 (4.2–8.3)2.3 (2.1–2.6)
    Age- and hypertension-adjusted RR1.05.3 (3.7–7.4)1.9 (1.7–2.1)
    Multivariate-adjusted RR1.04.7 (3.3–6.6)1.8 (1.7–2.0)
Ischemic stroke
    Cases1,08320373
    Incidence*42288140
    Age-adjusted RR1.07.9 (5.1–12.2)3.0 (2.6–3.4)
    Age- and hypertension-adjusted RR1.07.0 (4.5–10.9)2.4 (2.1–2.7)
    Multivariate-adjusted RR1.06.3 (4.0–9.8)2.3 (2.0–2.6)
Thrombotic stroke
    Cases84716313
    Incidence*33230118
    Age-adjusted RR1.08.0 (4.9–13.1)3.2 (2.8–3.6)
    Age- and hypertension-adjusted RR1.07.0 (4.3–11.5)2.5 (2.2–2.9)
    Multivariate-adjusted RR1.06.4 (3.9–10.5)2.4 (2.1–2.7)
Large-artery occlusive infarction
    Cases307695
    Incidence*128636
    Age-adjusted RR1.08.3 (3.7–18.7)2.7 (2.2–3.4)
    Age- and hypertension-adjusted RR1.07.6 (3.4–17.1)2.3 (1.8–2.9)
    Multivariate-adjusted RR1.07.2 (3.2–16.2)2.0 (1.6–2.6)
Lacunar infarction
    Cases3256132
    Incidence*138650
    Age-adjusted RR1.08.2 (3.7–18.4)3.6 (2.9–4.4)
    Age- and hypertension-adjusted RR1.07.4 (3.3–16.5)2.8 (2.3–3.5)
    Multivariate-adjusted RR1.07.2 (3.2–16.1)2.8 (2.3–3.5)
Hemorrhagic stroke
    Cases257331
    Incidence*104312
    Age-adjusted RR1.04.5 (1.4–14.1)1.1 (0.8–1.6)
    Age- and hypertension-adjusted RR1.04.3 (1.4–13.4)1.0 (0.7–1.4)
    Multivariate-adjusted RR1.03.8 (1.2–11.8)1.0 (0.7–1.4)
Stroke of unknown subtype
    Cases215488
    Incidence*85833
    Age-adjusted RR1.07.1 (2.6–19.1)3.4 (2.6–4.3)
    Age- and hypertension-adjusted RR1.05.9 (2.2–15.9)2.5 (1.9–3.2)
    Multivariate-adjusted RR1.04.7 (1.7–12.7)2.3 (1.7–3.0)
  • Data are n or RR (95% CI).

  • *

    * Incidence per 100,000 person-years.

  • Values were calculated by Cox proportional hazards model adjusted for age, BMI, physical activity, menopausal status and estrogen use, smoking and hypertension, high cholesterol, ischemic heart disease, aspirin use, and alcohol consumption.