Table 3—

Incidence rates and RRs of stroke subtypes by type 2 diabetes duration, the Nurses’ Health Study, 1976–2002

VariablesNo diabetesDuration of type 2 diabetes
<5 years5–9 years10–14 years15–19 years≥20 years
Total stroke
    Cases2,3847889126125211
    Incidence*92109155292360429
    Age-adjusted RR1.01.2 (0.9–1.4)1.5 (1.3–1.9)2.7 (2.3–3.3)3.3 (2.8–3.9)3.9 (3.4–4.5)
    Multivariate-adjusted RR1.01.1 (0.9–1.3)1.4 (1.1–1.8)2.4 (2.0–2.9)2.9 (2.4–3.5)3.3 (2.9–3.8)
Ischemic stroke
    Cases1,08350506777125
    Incidence*427087156222254
    Age-adjusted RR1.01.6 (1.2–2.2)1.9 (1.4–2.5)3.1 (2.4–4.0)4.4 (3.5–5.5)4.9 (4.1–5.9)
    Multivariate-adjusted RR1.01.5 (1.1–2.0)1.7 (1.3–2.3)2.8 (2.1–3.6)3.8 (3.0–4.8)4.1 (3.4–5.0)
Thrombotic stroke
    Cases84741415166111
    Incidence*335771118190226
    Age-adjusted RR1.01.7 (1.3–2.4)2.0 (1.5–2.7)3.0 (2.3–4.0)4.8 (3.7–6.2)5.6 (4.6–6.8)
    Multivariate-adjusted RR1.01.5 (1.1–2.1)1.8 (1.3–2.4)2.6 (1.9–3.5)4.0 (3.1–5.2)4.5 (3.7–5.6)
Large-artery occlusive infarction
    Cases3071813132525
    Incidence*122523307251
    Age-adjusted RR1.02.1 (1.3–3.3)1.8 (1.01–3.1)2.2 (1.3–3.8)5.2 (3.4–7.8)3.6 (2.4–5.5)
    Multivariate-adjusted RR1.01.7 (1.1–2.8)1.5 (0.8–2.6)1.8 (1.04–3.2)4.3 (2.8–6.5)2.9 (1.9–4.4)
Lacunar infarction
    Cases3251520262545
    Incidence*132135607292
    Age-adjusted RR1.01.6 (0.9–2.7)2.5 (1.6–3.9)4.1 (2.7–6.1)4.9 (3.3–7.4)6.3 (4.6–8.7)
    Multivariate-adjusted RR1.01.5 (0.9–2.5)2.3 (1.5–3.7)3.7 (2.5–5.6)4.5 (3.0–6.9)5.6 (4.1–7.8)
Hemorrhagic stroke
    Cases25777935
    Incidence*10101221910
    Age-adjusted RR1.01.0 (0.5–2.1)1.2 (0.6–2.5)1.9 (1.0–3.7)0.8 (0.3–2.5)0.9 (0.4–2.2)
    Multivariate-adjusted RR1.00.9 (0.4–2.0)1.1 (0.5–2.4)1.8 (0.9–3.6)0.7 (0.2–2.3)0.9 (0.2–2.1)
  • Data are n or RR (95% CI).

  • *

    * Incidence per 100,000 person-years.

  • Values calculated by Cox proportional hazards model adjusted for age, BMI, physical activity, menopausal status and estrogen use, smoking and hypertension, high cholesterol, ischemic heart disease, aspirin use, and alcohol consumption.