Table 2—

Summary of models, contrasts, and results

Tissue typeModelCovariatesnContrastRegionBrodmann's area(s)Cluster size (voxels)Corrected cluster PPeak voxel MNI coordinates (x, y, z)Peak voxel t
GreyDiabetic vs. HCAge, sex, GM108 vs. 51Diabetic < HCL calcarine, precuneus18, 172870.14−22, −66, 143.95
Diabetic > HCNone
GreyAny vs. NHAge, sex, GM, onset66 vs. 42AH < NHL temporal-occipital39, 37, 199010.001−52, −72, 204.88
L inferior occipital19, 185080.002−42, −84, −124.65
AH > NHNone
GreyHyperglycemia exposure scoreAge, sex, GM, onset98Negative correlationR cuneus, precuneus18, 19, 74640.0212, −74, 224.68
Positive correlationR prefrontal45, 46, 9, 84730.00846, 34, 363.87
L ventral prefrontal111630.18−10, 58, −244.39
WhiteDiabetic vs. HC subjectsAge, sex, WM108 vs. 51Diabetic < HCNone
Diabetic > HCNone
WhiteAH vs. NHAge, sex, WM, onset66 vs. 42AH < NHNone
AH > NHNone
WhiteHyperglycemia exposure scoreAge, sex, WM, onset98Negative correlationR superior parietalNear 5, 72970.0122, −54, 524.29
L superior parietalNear 5, 71780.13−22, −54, 404.22
Positive correlationNone
  • Regions with multiple-comparison corrected cluster level P < 0.20 are shown; significant results are in bold. Voxel dimensions are 2 × 2 x 2 mm. Peak voxel refers to the voxel with the greatest t value. AH, any hypoglycemia; GM, total grey matter volume; HC, healthy control; L, left; MNI, Montreal Neurological Institute; NH, no hypoglycemia; R, right; WM, total white matter volume.