Table 1—

Demographic and clinical profile by group and age of diagnosis of type 2 diabetes

Group A (duration of diabetes 20–30 years, n = 624)
Group B (duration of diabetes 10–12 years, n = 852)
Age of diagnosis (years)
PAge of diagnosis (years)
P
<4545–55>55<4545–55>55
n32223270236293323
Age at last examination (years)63.0 (53.8–66.4)72.8 (70.2–75.4)80.8 (78.8–83.0)<0.000150.2 (46.3–52.9)61.9 (59.4–64.0)71.8 (69.3–75.4)<0.0001
Duration (years)24.2 (21.7–27.2)22.8 (20.9–25.2)22.1 (20.7–23.7)<0.000110.9 (10.5–11.5)11.1 (10.5–11.6)10.9 (10.5–11.4)0.3
Male (%)55.053.957.10.959.858.051.10.08
Retinopathy (%)61.850.040.00.000639.842.324.8<0.0001
    OR (95% CI)2.4 (1.4–4.1)1.5 (0.9–2.6)10.0001 (Ptrend)2.0 (1.4–2.9)2.2 (1.6–3.1)1<0.0001 (Ptrend)
Vision-threatening retinopathy (%)26.420.312.20.0311.010.25.90.06
    OR (95% CI)2.4 (1.2–5.1)1.7 (0.8–3.7)10.009 (Ptrend)2.0 (1.1–3.7)1.8 (1.0–3.3)10.03 (Ptrend)
Mean A1C (%)8.4 ± 1.78.0 ± 1.38.2 ± 1.60.0068.7 ± 1.88.2 ± 1.67.9 ± 1.6<0.0001
Metabolic syndrome (%)77.072.073.50.564.771.268.80.5
Systolic blood pressure (mmHg)132 (120–150)138 (125–152)138 (128–152)0.2128 (117–140)136 (126–149)138 (127–153)<0.0001
Diastolic blood pressure (mmHg)72 (70–80)70 (65–80)70 (68–80)0.05180 (72–86)80 (70–85)76 (70–85)0.002
Blood pressure Rx (%)74.074.659.70.05151.672.278.8<0.001
Albuminuria (mg/l)23.7 (10.0–86.9)24.2 (10.0–92.0)26.7 (10.0–99.0)0.923.3 (9.0–83.3)16.5 (8.2–51.1)33.0 (11.0–104.3)0.002
BMI (kg/m2)30.0 (26.2–34.2)28.3 (25.5–32.1)27.6 (22.5–30.4)<0.000130.1 (26.5–33.5)29.7 (26.6–33.4)29.5 (26.1–32.6)0.09
HDL (mmol/l)1.2 (1.0–1.4)1.2 (1.0–1.6)1.2 (1.0–1.6)0.81.2 (0.9–1.4)1.1 (1.0–1.4)1.2 (1.0–1.5)0.01
    Triglycerides (mmol/l)1.8 (1.2–2.7)1.5 (1.1–2.2)1.7 (1.0–2.5)0.062.0 (1.3–2.9)1.7 (1.2–2.7)1.8 (1.3–2.6)0.1
  • Data are means ± SD and median (interquartile range) unless otherwise indicated. P refers to χ2 or ANOVA analysis of prevalence across the different age-of-onset subgroups; Ptrend refers to trend analysis of retinopathy prevalence across the different age-of-onset subgroups.