Table 1—

Receptor binding and metabolic and mitogenic potency of insulin analogs

Insulin receptor affinityMetabolic potencyIGF-I receptor affinityInsulin receptor off-rate (%)Mitogenic potency (Saos/B10 cells)
Human insulin100100100100100
B10 Asp205 ± 20207 ± 14587 ± 5014 ± 1975 ± 173
Insulin lispro84 ± 682 ± 3156 ± 16100 ± 1166 ± 10
Insulin aspart92 ± 6101 ± 281 ± 981 ± 858 ± 22
Insulin glargine8660 ± 3641 ± 51152 ± 13783 ± 13
Insulin detemir∼18–46∼2716 ± 1204 ± 9∼11
  • Data are means ± SD. Adapted from Kurtzhals et al. (43).