Table 1—

Clinical and biological characteristics at baseline of men and women with and without incident diabetes during the 9 years of the DESIR study

Men
Women
P for variableP for interaction with sex
DiabetesNo diabetesP*DiabetesNo diabetesP*
n1401,723631,891
Age (years)50 ± 947 ± 100.000152 ± 847 ± 100.00050.00010.6
Diabetes in the family28 (20)312 (18)0.627 (43)368 (19)0.00010.003
Current smoker52 (37)418 (24)0.000910 (16)249 (13)0.50.0010.3
Alcohol intake (g/day)§34 ± 3223 ± 220.0058 ± 117 ± 110.50.0060.2
Physical activity
    Little43 (31)422 (24)22 (35)465 (25)
    Moderate72 (51)911 (53)0.0733 (52)1036 (55)0.040.030.7
    Intensive25 (18)388 (23)8 (13)386 (20)
Waist circumference (cm)96 ± 1089 ± 90.000190 ± 1276 ± 100.00010.00010.3
BMI (kg/m2)§27.5 ± 4.025.1 ± 3.00.000129.2 ± 5.123.7 ± 3.80.00010.00010.3
Menopause30 (48)718 (38)0.1
Large baby, birth weight ≥4 kg16 (27)284 (15)0.02
Hypertension87 (62)678 (39)0.000139 (62)527 (28)0.00010.00010.1
Heart rate (min)68 ± 1066 ± 100.00771 ± 1168 ± 90.020.00050.7
Treatment for lipids20 (14)126 (7)0.0049 (14)129 (7)0.030.00030.9
Fasting glucose (mmol/l)§6.05 ± 0.555.39 ± 0.490.00015.96 ± 0.585.11 ± 0.460.00010.00010.1
GGT (IU/l)§64.3 ± 67.239.5 ± 38.30.000136.4 ± 33.621.7 ± 21.20.00010.00010.4
ALT (UI/l)§41.7 ± 28.330.3 ± 18.10.000128.9 ± 22.220.1 ± 13.80.00010.00010.4
Triglycerides (mmol/l)§1.79 ± 1.451.26 ± 0.800.00011.50 ± 0.780.93 ± 0.500.00010.006
HDL cholesterol (mmol/l)1.41 ± 0.371.50 ± 0.380.011.53 ± 0.341.80 ± 0.420.00010.008
Total cholesterol (mmol/l)6.06 ± 1.055.82 ± 0.970.0095.94 ± 1.045.61 ± 0.960.020.00010.6
Creatinine (μmol/l)91.0 ± 13.989.1 ± 11.10.0677.1 ± 10.774.1 ± 10.00.020.0060.4
White blood cell count (109/l)§6.9 ± 2.16.4 ± 1.70.0027.3 ± 4.06.2 ± 1.60.00020.00010.2
    n1351,617611,782
Number of TCF7L2 and IL6 deleterious alleles2.01.80.0082.21.80.030.00070.7
  • Data are means ± SD and n (%) unless otherwise indicated.

  • * P comparing means and percentages by t and χ2 tests.

  • P for variable in logistic model with only variable and sex, as interaction not significant.

  • P for variable not given, as the interaction is significant.

  • § Log transformation because of a nonsymmetric distribution.

  • Hypertension: systolic/diastolic blood pressure ≥140/90 mmHg or medication for hypertension.