Table 4—

Hypoglycemia risk by current exposure to sulfonylurea drugs, metformin, and/or insulin among case (n = 2,025) and control (n = 7,278) subjects

Exposure to antidiabetes drugs
Cases subjectsControl subjectsCrude odds ratio (95% CI)Adjusted odds ratio (95% CI)*P value
SulfonylureaMetforminInsulin
CurrentNoNo392 (19.4)1,213 (16.7)2.86 (2.31–3.55)2.79 (2.23–3.50)<0.0001
NoCurrentNo151 (7.5)1,383 (19.0)1.0 (reference)1.0 (reference)
NoNoCurrent7 (0.4)4 (0.1)14.9 (4.1–54.5)16.5 (4.2–65.0)<0.0001
CurrentCurrentNo526 (26.0)1,194 (16.4)4.07 (3.33–4.98)4.04 (3.27–4.98)<0.0001
CurrentNoCurrent17 (0.8)3 (0.04)50.5 (14.4–176)39.9 (11.2–142)<0.0001
NoCurrentCurrent53 (2.6)54 (0.7)8.72 (5.63–13.5)8.73 (5.49–13.9)<0.0001
CurrentCurrentCurrent19 (0.9)22 (0.3)8.61 (4.47–16.6)8.86 (4.47–17.6)<0.0001
  • Data are n (%) unless otherwise indicated.

  • *

    * Adjusted for use of other oral antidiabetes drugs, insulin, antihypertensive drugs, lipid-lowering agents, diuretics, inhaled and systemic corticosteroids, anticonvulsants, antidepressants, neuroleptics, benzodiazepines, stomach acid–reducing drugs, and analgesics.