Table 2—

Glycemic and blood pressure in year 4 by 3-year weight change–trajectory pattern

Higher stable weightLower stable weightWeight lossWeight gainP*
A1C measurements
    n (%)322 (16.9)1,135 (59.4)227 (11.9)227 (11.9)
    Above-goal mean A1C (%)153 (47.5)472 (41.6)63 (27.8)118 (52.0)<0.0001
    A1C (%)7.2 ± 1.3c7.0 ± 1.2ad6.6 ± 1.1bcd7.3 ± 1.4ab<0.0001
        Median (IQR)6.9 (6.3–7.8)6.8 (6.2–7.5)6.4 (5.8–7.1)7.0 (6.2–78.0)
    Mean A1C stratum (%)<0.0001
        <7169 (52.5)663 (58.4)164 (72.2)109 (48.0)
        7–887 (27.0)277 (24.4)41 (18.1)59 (26.0)
        8–937 (11.5)120 (10.6)14 (6.2)31 (13.7)
        ≥929 (9.0)75 (6.6)8 (3.5)28 (12.3)
Blood pressure measurements
    n (%)396 (16.4)1447 (60.1)285 (11.8)281 (11.7)
    Above-goal mean blood pressure (mmHg)291 (73.5)893 (61.7)172 (60.4)189 (67.3)<0.0001
    Systolic blood pressure (mmHg)135.9 ± 12.9ab132.9 ± 14.0a131.6 ± 13.2b133.4 ± 13.3<0.0001
        Median (IQR)135 (127–144)132 (123–141)131 (122–139)132 (125–140)
    Diastolic blood pressure (mmHg)80.1 ± 7.8ab77.1 ± 8.2bd77.4 ± 8.4ac79.3 ± 8.3cd<0.0001
        Median (IQR)80 (75–85)77 (71–82)79 (72–82)80 (74–84)
    Mean systolic blood pressure stratum (mmHg)0.0364
        ≤130143 (36.1)650 (44.9)135 (47.4)133 (47.3)
        130–139110 (27.8)389 (26.9)81 (28.4)69 (24.6)
        140–159125 (31.6)355 (24.5)61 (21.4)69 (24.6)
        ≥16018 (4.5)53 (3.7)8 (2.8)10 (3.5)
    Mean diastolic blood pressure stratum (mmHg)<0.0001
        ≤80198 (50.0)970 (67.0)182 (63.9)151 (53.7)
        80–89155 (39.1)385 (26.6)82 (28.8)104 (37.0)
        90–9940 (10.1)84 (5.8)19 (6.6)24 (8.6)
        ≥1003 (0.8)8 (0.6)2 (0.7)2 (0.7)
  • Data are n (%) and means ± SD unless otherwise indicated.

  • * Comparison across all 4 groups.

  • Includes those with one or more measures during year 4.

  • abcd Means with the same superscripts are significantly different from one another at P < 0.05. IQR, interquartile range.