Table 1—

Clinical features of women with PCOS and control subjects

ControlPCOS
n187287
Age (years)33.0 (17.0)27.5 (11.5)*
BMI (kg/m2)24.1 (6.4)34.7 (13.5)*
WHR0.78 (0.08)0.83 (0.10)*
mFG score0 (0)7.0 (5.0)*
Hirsute (%)073.9*
Total testosterone (nmol/l)1.42 (0.92)2.77 (1.07)*
Free testosterone (pmol/l)12.1 (9.0)29.1 (16.3)*
DHEAS (μmol/l)2.58 (2.03)5.66 (4.61)*
SHBG (nmol/l)220.0 (120.0)150.0 (70.0)*
Insulin (pmol/l)49.5 (45.9)129.15 (129.2)*
Glucose (mmol/l)4.77 (0.56)4.77 (0.72)
HOMA-IR0.92 (0.83)2.29 (1.93)*
HOMA-%B103.9 (59.5)175.3 (99.3)*
  • Data are median (interquartile range).

  • *

    * P < 0.001 compared with control group.

  • SHBG activity was measured by competitive binding analysis using Sephadex G-25 and [3H]testosterone as the ligand; this assay gives values of approximately 100–300 nmol/l in normal adult women. DHEAS, dehydroepiandrosterone sulfate; HOMA-%B, β-cell function estimated by the homeostasis model assessment; HOMA-IR, insulin resistance estimated by the homeostasis model assessment; mFG score, modified Ferriman-Gallwey hirsutism score; SHBG, sex hormone–binding globulin; WHR, waist-to-hip ratio.