Model | Independent variables | OR (95% CI) | P value |
---|---|---|---|
Independence | Carrier state (Y/N) for AKT2 risk haplotype* | 2.10 (1.2–3.7) | 0.010 |
Carrier state (Y/N) for GSK3B risk haplotype* | 1.80 (1.0–3.1) | 0.036 | |
Additive | Number of AKT2 or GSK3B risk haplotypes† | 1.58 (1.1–2.2) | 0.010 |
Combined | Carrier state (Y/N) for both risk haplotypes in AKT2 and GSK3B‡ | 3.11 (1.4–6.9) | 0.0050 |
PCOS diagnosis was the dependent variable in all models. Each analysis also included age and BMI as independent variables.
↵* Carriers are homozygous or heterozygous for risk haplotype (T-G-C-T in AKT2 and C-A-C-C-G-G-A-G-G in GSK3B).
↵† Number of risk haplotypes per individual is 0–4.
↵‡ Compares subjects who are carriers of at least one AKT2 risk haplotype and at least one GSK3B risk haplotype to all other subjects.