Table 1—

Demographic data and performance of GFR estimation equations

All subjectsGroup 1Group 2Group 3
n293999797
Mean weight (kg)91.974.391.2110.5
Male/female221/7261/3871/2184/13
Age (years)55.2 ± 9.4 (55.0 [49.0–62.8])57.3 ± 9.9 (60.0 [50.8–65.0])56.3 ± 8.6 (57.0 [50.0–63.0])51.9 ± 8.9 (51.0 [46.5–58.0])
Weight (kg)91.9 ± 17.0 (91.5 [80.3–102.5])74.3 ± 7.8 (75.8 [69.9–80.4])91.2 ± 4.1 (91.5 [87.3–94.8])110.5 ± 11.6 (106.9 [102.5–114.3])
A1C (%)7.79 ± 2.00 (7.2 [6.3–9.1])7.87 ± 2.18 (7.2 [6.2–9.3])7.69 ± 1.74 (7.4 [6.4–9.1])7.81 ± 2.06 (7.0 [6.5–9.0])
Fasting plasma glucose(mmol/l)9.67 ± 3.04 (8.7 [7.4–11.4])9.69 ± 3.29 (8.6 [7.3–11.7])9.48 ± 2.75 (8.9 [7.1–11.4])9.83 ± 3.07 (9.0 [7.7–11.2])
Creatinine (μmol/l)80.0 ± 14.8 (80.0 [69.3–90.0])76.8 ± 14.3 (76.0 [66.8–86.3])81.1 ± 15.3 (80.0 [70.0–89.0])82.0 ± 14.3 (83.0 [71.5–92.5])
AER (mg/day)10.9 ± 34.77.2 ± 15.29.6 ± 22.416.1 ± 42.8
iGFR114.9 ± 22.4 (111.0 [98.0–130.0])110.8 ± 20.4 (107.0 [96.0–125.0])113.8 ± 21.8 (109.0 [98.0–130.50])120.1 ± 24.0 (116.0 [102.0–138.5])
CGMDRDCGMDRDCGMDRDCGMDRD




eGFR101.2 ± 26.889.9 ± 19.090.2 ± 20.589.5 ± 17.699.1 ± 24.389.0 ± 19.9114.5 ± 29.491.2 ± 19.5
Bias (95% CI)−13.7 (−16.0 to −11.4)−25.0 (−26.9 to −23.1)−20.6 (−23.9 to −17.3)−21.3 (−24.6 to −18.0)−14.7 (−18.5 to −10.9)−24.8 (−28.1 to −21.5)−5.6 (−9.8 to −1.4)−28.9 (−32.1 to −25.7)
Precision (95% LOA)19.7 (−52.3 to 24.9)16.6 (−57.5 to 7.6)16.3 (−52.6 to 11.4)16.6 (−53.7 to 11.2)18.9 (−51.8 to 22.3)16.5 (−57.1 to 7.5)20.9 (−46.6 to 35.3)16.0 (−60.3 to 2.5)
10% accuracy30 (24–35)15 (11–19)20 (12–28)20 (12–28)30 (21–39)14 (7–22)39 (29–49)10 (4–16)
30% accuracy86 (82–90)79 (74–84)80 (72–88)88 (81–94)84 (76–91)74 (65–83)94 (89–99)74 (65–83)
r20.4810.4750.4650.3960.4430.4780.5050.558
  • Data are means ± SD, median [interquartile range], or percent (95% CI) unless otherwise indicated. All r2 values were positive and statistically significantly different from zero. Bias is calculated as the mean difference between eGFR and measured (isotopic GFR [iGFR]) values. Precision is the SD of the bias (95% limits of agreement [LOA]) of eGFR and isotopic GFR. Accuracy reflects the proportion of eGFR values within 10% and 30% of isotopic GFR. r2 values of eGFR vs. isotopic GFR are shown. AER, albumin excretion rate; CG, Cockcroft-Gault.