Table 1—

Baseline clinical data in 108 women with type 1 diabetes according to experience of severe hypoglycemia in pregnancy

Women without severe hypoglycemia in pregnancyWomen with severe hypoglycemia in pregnancy
n59 (55)49 (45)
Age (years)31 (21–42)30 (21–39)
Duration of diabetes (years)13 (1–36)19 (2.5–31)*
Gestational age at inclusion (days)61 (37–94)62 (42–93)
Last A1C before pregnancy (%)7.5 (5.9–10.0)7.0 (5.9–10.9)
BMI before pregnancy (kg/m2)24.1 (17.3–43.8)24.4 (20.1–32.4)
Insulin type (human insulin/insulin analogs)32 (54)/27 (46)28 (57)/21 (43)
Number of daily insulin injections (4/5/CSII) (%)56/42/267/25/8
Diabetic retinopathy35 (59)33 (67)
Microalbuminuria/nephropathy6 (10)/3 (5)4 (8)/3 (6)
Antihypertensive treatment at inclusion5 (8)10 (20)
Systolic blood pressure (mmHg)119 (95–150)119 (88–150)
Diastolic blood pressure (mmHg)70 (55–86)71 (59–85)
Severe hypoglycemia the year preceding pregnancy10 (17)23 (47)
SMPG threshold for mild hypoglycemic events before pregnancy3.0 (1.5–4.0)2.7 (1.5–4.5)*
  • Data are median (range) or n (%) unless otherwise indicated.

  • * P < 0.01;

  • P < 0.001. CSII, continuous subcutaneous insulin infusion.