Metabolic parameters in 49 women with (+SH) and 59 women without (−SH) severe hypoglycemia in pregnancy with type 1 diabetes
| Week 8 | Week 14 | Week 21 | Week 27 | Week 33 | |
|---|---|---|---|---|---|
| Median SMPG (mmol/l) | |||||
| −SH | 6.4 (4.0–11) | 6.8 (4.3–11) | 6.7 (4.0–10) | 6.8 (3.9–11) | 5.9 (4.2–10)* |
| +SH | 6.8 (4.0–13) | 6.7 (3.9–14) | 6.7 (4.6–12) | 6.8 (4.9–9) | 6.4 (4.1–10) |
| Biochemical hypoglycemia SMPG ≤3.9 mmol/l (%) | |||||
| −SH | 16 (4–44) | 13 (0–46) | 13 (0–48) | 12 (0–50) | 15 (0–39) |
| +SH | 17 (0–50) | 17 (0–54) | 14 (0–35) | 13 (0–36) | 17 (0–46) |
| SMPG outside the range of 4.0–9.9 mmol/l (%) | |||||
| −SH | 34 (8–70) | 36 (8–82) | 36 (4–59) | 29 (0–65) | 29 (4–58)† |
| +SH | 48 (16–84)‡ | 39 (8–81) | 36 (0–69) | 27 (0–61) | 36 (0–58)† |
| Biochemical hyperglycemia SMPG ≥10.0 mmol/l (%) | |||||
| −SH | 16.7 (0–57) | 16.7 (0–57) | 18.2 (0–48) | 14.3 (0–50) | 8.3 (0–40)† |
| +SH | 21.5 (0–72) | 21.7 (0–67) | 19.5 (0–65) | 12.5 (0–42) | 9.1 (0–52)* |
| Median SMPG at 3:00 a.m.§ | |||||
| −SH | 5.9 (1.8–14) | 6.5 (2.2–18) | 6.2 (1.9–14) | 5.7 (1.9–13) | 5.1 (2.1–16)* |
| +SH | 7.9 (2.1–16) | 7.0 (2.6–16) | 6.3 (3–13) | 7.0 (2.9–11) | 5.8 (2.7–13) |
| A1C (%) | |||||
| −SH | 6.7 (4.9–8.8) | 6.4 (5.2–7.9) | 6.0 (4.9–7.1) | 5.9 (4.9–6.9) | 5.9 (5.0–7.3)† |
| +SH | 6.5 (5.2–10.5) | 6.3 (5.1–7.8) | 6.0 (5.0–7.7) | 5.9 (5.0–7.2) | 5.9 (4.8–7.2)† |
| Insulin dosage (IU/kg) | |||||
| −SH | 0.76 (0.4–1.2) | 0.68 (0.4–1.2) | 0.78 (0.4–1.4) | 0.90 (0.5–1.7) | 1.12 (0.5–1.9)† |
| +SH | 0.76 (0.3–1.7) | 0.68 (0.3–1.5) | 0.73 (0.3–1.2) | 0.90 (0.4–1.6) | 1.04 (0.5–1.6)† |
| Self-estimated impaired awareness | |||||
| −SH | 25 (43) | 25 (49) | 28 (54) | 25 (46) | 26 (47) |
| +SH | 36 (75)‖ | 33 (73)¶ | 35 (85)‡ | 34 (81)‡ | 31 (72)¶ |
| Number of mild hypoglycemic events previous week | |||||
| −SH | 5 (0–21) | 4.5 (0–12) | 4 (0–12)§ | 3 (0–13) | 4 (0–14)* |
| +SH | 4 (0–21) | 4 (0–14) | 3 (0–8) | 3 (0–25) | 3 (0–15)* |
| SMPG threshold for mild hypoglycemic events | |||||
| −SH | 2.8 (1.5–4.0) | 3.0 (1.8–4.5) | 3.0 (1.9–4.0) | 3.0 (1.9–4.0) | 2.8 (1.8–3.8) |
| +SH | 2.7 (1.5–4.0) | 2.8 (1.6–4.0) | 2.7 (1.8–3.8) | 2.7 (1.8–4.0) | 2.8 (1.9–4.0) |
| Nausea or vomiting previous week | |||||
| −SH | 37 (63) | 25 (50) | 17 (32) | 12 (22) | 19 (34)# |
| +SH | 27 (56) | 14 (30) | 11 (26) | 9 (21) | 11 (25)* |