Table 2—

Metabolic parameters in 49 women with (+SH) and 59 women without (−SH) severe hypoglycemia in pregnancy with type 1 diabetes

Week 8Week 14Week 21Week 27Week 33
Median SMPG (mmol/l)
    −SH6.4 (4.0–11)6.8 (4.3–11)6.7 (4.0–10)6.8 (3.9–11)5.9 (4.2–10)*
    +SH6.8 (4.0–13)6.7 (3.9–14)6.7 (4.6–12)6.8 (4.9–9)6.4 (4.1–10)
Biochemical hypoglycemia SMPG ≤3.9 mmol/l (%)
    −SH16 (4–44)13 (0–46)13 (0–48)12 (0–50)15 (0–39)
    +SH17 (0–50)17 (0–54)14 (0–35)13 (0–36)17 (0–46)
SMPG outside the range of 4.0–9.9 mmol/l (%)
    −SH34 (8–70)36 (8–82)36 (4–59)29 (0–65)29 (4–58)
    +SH48 (16–84)39 (8–81)36 (0–69)27 (0–61)36 (0–58)
Biochemical hyperglycemia SMPG ≥10.0 mmol/l (%)
    −SH16.7 (0–57)16.7 (0–57)18.2 (0–48)14.3 (0–50)8.3 (0–40)
    +SH21.5 (0–72)21.7 (0–67)19.5 (0–65)12.5 (0–42)9.1 (0–52)*
Median SMPG at 3:00 a.m.§
    −SH5.9 (1.8–14)6.5 (2.2–18)6.2 (1.9–14)5.7 (1.9–13)5.1 (2.1–16)*
    +SH7.9 (2.1–16)7.0 (2.6–16)6.3 (3–13)7.0 (2.9–11)5.8 (2.7–13)
A1C (%)
    −SH6.7 (4.9–8.8)6.4 (5.2–7.9)6.0 (4.9–7.1)5.9 (4.9–6.9)5.9 (5.0–7.3)
    +SH6.5 (5.2–10.5)6.3 (5.1–7.8)6.0 (5.0–7.7)5.9 (5.0–7.2)5.9 (4.8–7.2)
Insulin dosage (IU/kg)
    −SH0.76 (0.4–1.2)0.68 (0.4–1.2)0.78 (0.4–1.4)0.90 (0.5–1.7)1.12 (0.5–1.9)
    +SH0.76 (0.3–1.7)0.68 (0.3–1.5)0.73 (0.3–1.2)0.90 (0.4–1.6)1.04 (0.5–1.6)
Self-estimated impaired awareness
    −SH25 (43)25 (49)28 (54)25 (46)26 (47)
    +SH36 (75)33 (73)35 (85)34 (81)31 (72)
Number of mild hypoglycemic events previous week
    −SH5 (0–21)4.5 (0–12)4 (0–12)§3 (0–13)4 (0–14)*
    +SH4 (0–21)4 (0–14)3 (0–8)3 (0–25)3 (0–15)*
SMPG threshold for mild hypoglycemic events
    −SH2.8 (1.5–4.0)3.0 (1.8–4.5)3.0 (1.9–4.0)3.0 (1.9–4.0)2.8 (1.8–3.8)
    +SH2.7 (1.5–4.0)2.8 (1.6–4.0)2.7 (1.8–3.8)2.7 (1.8–4.0)2.8 (1.9–4.0)
Nausea or vomiting previous week
    −SH37 (63)25 (50)17 (32)12 (22)19 (34)#
    +SH27 (56)14 (30)11 (26)9 (21)11 (25)*
  • Data are median (range) or n (%).

  • * P < 0.05,

  • P < 0.0001, and

  • # P < 0.001 between week 33 and week 8.

  • P < 0.01,

  • P < 0.001, and

  • P < 0.05 between the two groups. Data were obtained from 85 to 100% of the patients except §where 75% of samples were obtained.