Table 2—

HRs (95% CI) of foot ulcer and LEA for the full dataset and for foot ulcer and LEA

A. Full datasetFoot ulcerFoot ulcer adjustedLEALEA adjusted (includes an interaction term for PAD)
CKD (eGFR)
    ≥60 ml/min per 1.73 m2RefRefRefRef
    ≥30 to <60 ml/min per 1.73 m21.85 (1.71–2.01)1.51 (1.38–1.66)2.08 (1.68–2.58)2.28 (1.54–3.36)
    <30 ml/min per 1.73 m23.92 (3.23–4.75)3.22 (2.60–4.00)7.71 (5.29–1.26)8.05 (4.23–7.01)
B. Foot ulcerFoot ulcer without PADFoot ulcer without PAD adjustedFoot ulcer with PADFoot ulcer with PAD adjusted
CKD (eGFR)
    ≥60 ml/min per 1.73 m2RefRefRefRef
    ≥30 to <60 ml/min per 1.73 m21.68 (1.51–1.86)1.41 (1.24,1.58)1.44 (1.26,1.65)1.38 (1.18–1.60)
    <30 ml/min per 1.73 m23.86 (3.00–4.98)3.32 (2.55–4.33)2.10 (1.56,2.84)2.04 (1.49–2.79)
C. LEALEA without PADLEA without PAD adjustedLEA with PADLEA with PAD adjusted
CKD (eGFR)
    ≥60 ml/min per 1.73 m2RefRefRefRef
    ≥30 to <60 ml/min per 1.73 m21.82 (1.28–2.60)2.05 (1.37–3.07)1.31 (1.00–1.72)*1.60 (1.19–2.16)
    <30 ml/min per 1.73 m26.96 (3.50–13.83)7.80 (3.82–15.90)2.90 (1.76,4.76)3.33 (1.93–5.77)
  • Adjusted and unadjusted results are shown. Parts B and C include results in the presence or absence of peripheral arterial disease. Compared with reference (Ref) or as a test for trend, all P values <0.001 unless

  • *

    * P = 0.05.