Table 3—

Association between adiponectin and incident type 2 diabetes with addition of leptin, CRP, IL-6, and/or SAA: the Sandy Lake Health and Diabetes Project

AdiponectinLeptinCRPIL-6SAAC Statistic*
Base model0.45 (0.25–0.81)0.753
+ Leptin0.45 (0.25–0.81)0.98 (0.55–1.74)0.753
+ CRP0.45 (0.25–0.81)0.99 (0.77–1.26)0.753
+ IL-60.45 (0.25–0.81)0.98 (0.74–1.31)0.753
+ SAA0.46 (0.26–0.81)1.07 (0.79–1.47)0.754
+ Leptin + CRP0.45 (0.25–0.81)1.00 (0.97–1.03)0.98 (0.77–1.26)0.753
+ Leptin + CRP + IL-60.45 (0.25–0.81)1.00 (0.97–1.03)0.99 (0.76–1.28)0.99 (0.72–1.35)0.753
+ Leptin + CRP + IL-6 + SAA0.45 (0.25–0.81)1.00 (0.97–1.03)0.95 (0.70–1.27)0.97 (0.71–1.33)1.13 (0.77–1.65)0.755
  • Data are OR (95% CI) per 1-unit change (n = 479).

  • *

    * There were no significant differences between the C statistics of the baseline model and subsequent models adjusted with additional adipokine(s).

  • Outcome = incident diabetes; 1° exposure = adiponectin, with adjustment for age, sex, triglyceride, HDL cholesterol, hypertension, impaired glucose tolerance, and waist circumference.