Table 2—

Percent change in risk factors for cardiovascular disease and diabetes over year 1 in those randomized to placebo

MenWomen
n335747
Cardiometabolic risk factors
    Fasting glucose0.0 ± 11.9−0.9 ± 11.9
    TG−5.1 ± 46.8−5.1 ± 40.8
    HDL0.0 ± 15.60.0 ± 17.6
    BP−0.8/−1.3 ± 13/14−0.9/−1.3 ± 13/16
    Waist circumference−0.2 ± 4.8−0.5 ± 6.1
    Weight0.0 ± 3.70.1 ± 4.5
    BMI0.0 ± 3.80.1 ± 5.2
Physical activity12.5 ± 1256.6 ± 162
Caloric intake−8.5 ± 42.7−9.7 ± 36.9
% on meds for TG or BP0.58.3
Diabetes risk factors
    2-h glucose−6.9 ± 30.4−4.8 ± 27.5
    A1C0.02 ± 0.060.00 ± 0.06
    Insulin5.0 ± 53.20.0 ± 57.1
Index of insulin secretion
    CIR−4.1 ± 57.1−2.3 ± 59.4
Index of insulin action
    HOMA-IR5.3 ± 61.00.2 ± 64.9
  • Data are medians ± interquartile range. BP, blood pressure; TG, triglyceride.

  • P < 0.05, men vs. women.