Table 3—

Percent change in risk factors for cardiovascular disease and diabetes over year 1 in those randomized to ILS

<3% weight loss
3–7% weight loss
>7% weight loss
MenWomenMenWomenMenWomen
n4815986181178322
Cardiometabolic risk factors
    Fasting glucose−3.8 ± 15.1−1.0 ± 10.7−4.4 ± 10.5−3.9 ± 9.8−6.8 ± 11−7.6 ± 9.1
    TG−4.3 ± 42.91.5 ± 37.5−13.3 ± 43−11.1 ± 38−28 ± 43−19 ± 40*
    HDL0.0 ± 16.1−2.0 ± 17.52.8 ± 212.0 ± 176.5 ± 184.6 ± 20
    BP1.2/0.0 ± 12/120.8/0.0 ± 12/14−1.1/−3.6 ± 15/15−2.1/−4.1 ± 14/15−6.4/−8.9 ± 13/14−4.9/−7.6 ± 12/14
    Waist circumference−2.1 ± 5.4−1.3 ± 5.2−4.9 ± 4.0−4.7 ± 5.2−9.3 ± 6.58.7 ± 6.9
    BMI−0.8 ± 2.5−0.6 ± 2.7−5.4 ± 1.85.0 ± 2.2−10.2 ± 5.5−11.1 ± 5.7
Physical activity51 ± 16730 ± 18743 ± 16242 ± 23067 ± 22192 ± 281
Caloric intake−8.4 ± 40−19.2 ± 38−17.5 ± 47−22.4 ± 36−18.7 ± 36−21.1 ± 39
% on meds for TG or BP0.00.00.00.00.00.0
Diabetes risk factors
    2-h glucose−6.9 ± 30−5.2 ± 27−22 ± 29−13 ± 27*−26 ± 30−19 ± 26*
    A1C−0.02 ± 0.050.00 ± 0.07−0.02 ± 0.05−0.02 ± 0.05−0.03 ± 0.06−0.02 ± 0.05
    Insulin−2.9 ± 49−5.9 ± 52−19 ± 50−11 ± 49−39 ± 41−33 ± 40
Index of insulin secretion
    CIR−0.9 ± 652.7 ± 610.9 ± 69−3.1 ± 653.6 ± 684.3 ± 66
Index of insulin action
    HOMA-IR−4.4 ± 70−6.0 ± 61−25 ± 49−15 ± 51−40–5 ± 44−39 ± 37
  • Data are medians ± interquartile range. BP, blood pressure; TG, triglyceride.

  • *

    * P < 0.01, men vs. women;

  • P < 0.05, men vs. women.