Table 1—

Odds ratios (ORs) and 95% CIs between diabetic men and women for CVD risk factors not under control, as well as for intensity of medication management* for each CVD risk factor among patients with levels not under control (unadjusted and adjusted estimates using male sex as the referent)

With CVD (n = 9,521 men and 8,050 women)
Without CVD (n = 12,417 men and 14,905 women)
OR95% CIPOR95% CIP
CVD risk factors not in control (unadjusted)
    SBP ≥140 mmHg1.201.12–1.27<0.00011.081.03–1.130.003
    LDL cholesterol ≥130 mg/dl1.331.25–1.42<0.00011.211.15–1.28<0.0001
    A1C ≥ 8%1.040.97–1.110.321.010.95–1.070.82
CVD risk factors not in control (multiple adjusted)
    SBP ≥140 mmHg1.191.11–1.29<0.00011.00.95–1.060.99
    LDL cholesterol ≥130 mg/dl1.441.33–1.55<0.00011.251.18–1.32<0.0001
    A1C ≥8%1.151.06–1.250.00091.040.97–1.10.29
Intensity of medication management (unadjusted)
    ≥2 antihypertensive agents1.091.02–1.160.0141.191.12–1.26<0.0001
    ≥1 lipid-lowering drug0.760.72–0.81<0.00010.990.93–1.040.62
    ≥2 oral antihyperglycemic agents or insulin1.111.03–1.180.0031.050.995–1.110.073
Intensity of medication management (multiple adjusted)
    ≥2 antihypertensive agents0.9980.92–1.080.971.010.95–1.080.71
    ≥1 lipid-lowering drug0.850.79–0.91<0.00010.990.93–1.050.65
    ≥2 oral antihyperglycemic agents or insulin1.040.95–1.130.400.960.9–1.030.25
  • *

    * Outcomes analyzed as binary variables (≥140 vs. <140 mmHg for SBP, ≥130 vs. <130 mg/dl for LDL cholesterol, and ≥8.0 vs. <8.0% for A1C) according to the levels considered not in control and therefore requiring more action, as recommended by the American Diabetes Association. More intense medication management was defined as the use of two or more drug classes of antihypertensive agents for hypertension, of one or more lipid-lowering agents for lipid management, and of two or more oral agents or insulin for antihyperglycemic treatment.