Table 2—

Effect of interventions on biochemical variables

PlaceboFenofibrateCoQCombinationP for interactionFenofibrate main effectPCoQ main effectP
n20161617
Fasting glucose (mmol/l)
    Baseline7.2 ± 0.46.8 ± 0.37.6 ± 0.47.7 ± 0.5
    End7.4 ± 0.37.1 ± 0.37.7 ± 0.47.2 ± 0.40.404−0.3 ± 0.30.294−0.1 ± 0.30.659
GHb (%)
    Baseline6.5 ± 0.26.2 ± 0.16.6 ± 0.26.6 ± 0.2
    End6.4 ± 0.25.9 ± 0.26.5 ± 0.26.5 ± 0.20.184−0.2 ± 0.10.1360.1 ± 0.10.483
Total cholesterol (mmol/l)
    Baseline4.4 ± 0.34.7 ± 0.24.6 ± 0.24.5 ± 0.2
    End4.3 ± 0.24.5 ± 0.24.7 ± 0.24.1 ± 0.20.086−0.3 ± 0.20.0690.0 ± 0.20.966
Triglycerides (mmol/l)
    Baseline1.6 ± 0.21.6 ± 0.21.7 ± 0.21.7 ± 0.2
    End1.8 ± 0.21.2 ± 0.11.6 ± 0.11.1 ± 0.10.615−0.6 ± 0.1<0.001−0.2 ± 0.10.070
HDL cholesterol (mmol/l)
    Baseline1.22 ± 0.061.28 ± 0.101.25 ± 0.061.36 ± 0.10
    End1.20 ± 0.061.38 ± 0.101.24 ± 0.071.33 ± 0.090.0680.05 ± 0.040.150−0.06 ± 0.040.107
LDL cholesterol (mmol/l)
    Baseline2.5 ± 0.22.7 ± 0.22.6 ± 0.22.4 ± 0.2
    End2.3 ± 0.22.6 ± 0.22.7 ± 0.22.3 ± 0.20.081−0.1 ± 0.10.4420.2 ± 0.10.286
ApoA-I (g/l)
    Baseline1.35 ± 0.051.42 ± 0.071.40 ± 0.051.51 ± 0.07
    End1.39 ± 0.051.57 ± 0.081.42 ± 0.051.56 ± 0.080.3970.09 ± 0.040.028−0.06 ± 0.040.134
ApoA-II (g/l)
    Baseline0.32 ± 0.010.32 ± 0.010.33 ± 0.010.32 ± 0.01
    End0.32 ± 0.010.39 ± 0.020.33 ± 0.010.39 ± 0.020.8710.08 ± 0.01<0.0010.00 ± 0.010.706
ApoB-100 (g/l)
    Baseline0.90 ± 0.060.96 ± 0.040.98 ± 0.050.91 ± 0.04
    End0.88 ± 0.050.88 ± 0.050.98 ± 0.050.77 ± 0.040.113−0.10 ± 0.040.008−0.01 ± 0.040.793
ApoC-III (mg/l)
    Baseline125.8 ± 8.2125.8 ± 10.0130.9 ± 6.8126.1 ± 8.9
    End129.8 ± 8.6103.0 ± 8.3130.7 ± 5.695.8 ± 5.80.588−29.1 ± 4.4<0.001−5.1 ± 4.40.250
NEFAs (mmol/l)
    Baseline0.40 (0.30–0.52)0.34 (0.27–0.43)0.37 (0.26–0.54)0.32 (0.23–0.44)
    End0.38 (0.28–0.51)0.29 (0.20–0.40)0.37 (0.29–0.48)0.27 (0.19–0.37)0.836−0.080.0570.010.866
Plasma CoQ (μmol/l)
    Baseline1.5 (1.2–1.8)1.8 (1.5–2.3)1.7 (1.4–2.2)1.5 (1.2–1.8)
    End1.4 (1.2–1.8)1.8 (1.5–2.2)5.3 (3.9–7.2)4.1 (3.1–5.4)0.0900.20.2503.2<0.001
Cellular CoQ (nmol/g protein)
    Baseline108 (94–125)107 (95–120)123 (105–145)118 (105–132)
    End116 (97–39)101 (91–112)147 (119–183)139 (125–153)0.582−120.203330.001
  • Data are means ± SEM or geometric means (95% CI). Main effect vs. placebo, adjusted for baseline and study site (general linear model).