Table 4—

Effect of interventions on ABP and HR

PlaceboFenofibrateCoQCombinationP for interactionFenofibrate main effectPCoQ main effectP
n15151014
24-h
    SBP (mmHg)
Baseline125.4 ± 1.5130.3 ± 2.8126.2 ± 3.6125.7 ± 3.1
End126.0 ± 2.5130.2 ± 3.2125.9 ± 4.7123.0 ± 2.60.001
    DBP (mmHg)
Baseline73.8 ± 2.373.1 ± 1.973.5 ± 2.072.3 ± 1.9
End74.3 ± 2.972.1 ± 1.972.3 ± 2.770.1 ± 1.60.732−1.3 ± 0.50.013−2.2 ± 0.5< 0.001
    HR (bpm)
Baseline73.9 ± 2.872.3 ± 2.770.4 ± 2.573.3 ± 2.8
End74.5 ± 2.570.2 ± 2.972.7 ± 2.370.9 ± 2.40.859−3.3 ± 0.5< 0.0010.2 ± 0.50.716
Awake
    SBP (mmHg)130.3 ± 1.6134.5 ± 2.8130.8 ± 2.9130.1 ± 3.3
Baseline130.5 ± 2.9134.3 ± 3.0130.4 ± 4.6129.0 ± 2.70.035
End
    DBP (mmHg)77.9 ± 2.576.2 ± 1.777.3 ± 1.876.2 ± 2.1
Baseline78.5 ± 3.075.3 ± 1.976.1 ± 3.074.3 ± 1.60.275−0.6 ± 0.60.319−2.7 ± 0.6< 0.001
End
    HR (bpm)
Baseline77.0 ± 3.175.8 ± 3.173.2 ± 2.976.2 ± 3.2
End77.5 ± 2.672.6 ± 3.375.8 ± 2.674.9 ± 2.70.285−3.0 ± 0.7< 0.0010.6 ± 0.60.305
Asleep
    SBP (mmHg)
Baseline114.6 ± 2.0120.6 ± 3.4116.4 ± 6.3117.0 ± 3.3
End116.5 ± 2.6120.0 ± 3.7117.9 ± 5.5111.4 ± 2.90.002
    DBP (mmHg)
Baseline65.1 ± 2.265.8 ± 2.264.9 ± 3.264.6 ± 1.8
End65.8 ± 2.664.9 ± 2.066.7 ± 3.161.4 ± 1.80.392−2.6 ± 0.90.005−1.3 ± 0.90.139
    HR (bpm)
Baseline67.4 ± 2.365.1 ± 2.364.8 ± 2.367.3 ± 2.2
End68.5 ± 2.564.0 ± 2.667.2 ± 2.263.2 ± 2.10.381−3.5 ± 0.7< 0.001−0.1 ± 0.60.858
  • Data are means ± SEM. Main effect vs. placebo, adjusted for baseline, study site, hour, change in weight, and antihypertensive medication use (mixed models).