Prediction of progression based on Cox proportional hazards models using the baseline data for all variables
Adjusted for | Adjusted for the model and | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable and adjustment | Unadjusted or adjusted for sex | Total cholesterol | Smoking history | HbA1c | WHR | TGs | eGFR | Adjusted for PM | AER | KIM-1 | L-FABP | Serum ADP |
Normal AER | ||||||||||||
uADP | ||||||||||||
No | 1.32 (<0.001) | 1.29 (0.002) | 1.31 (0.001) | 1.17 (0.07) | 1.40 (<0.001) | — | — | 1.22 (0.02) | 0.98 (0.80) | 0.96 (0.76) | 0.98 (0.90) | 1.22 (0.07) |
Sex | 1.39 (<0.001) | 1.36 (<0.001) | 1.39 (<0.001) | 1.24 (0.01) | 1.42 (<0.001) | — | — | 1.25 (0.01) | 0.99 (0.91) | 0.97 (0.81) | 1.01 (0.94) | 1.26 (0.04) |
Microalbuminuria | ||||||||||||
uADP | ||||||||||||
No | 1.38 (0.007) | — | — | 1.29 (<0.05) | 1.45 (0.002) | 1.37 (0.008) | — | 1.34 (0.03) | 1.01 (0.95) | 1.31 (0.07) | 1.02 (0.92) | 1.30 (0.14) |
Sex | 1.46 (0.001) | — | — | 1.35 (0.02) | 1.46 (0.001) | 1.42 (0.003) | — | 1.35 (0.02) | 1.02 (0.89) | 1.31 (0.06) | 1.04 (0.83) | 1.29 (0.15) |
Macroalbuminuria | ||||||||||||
uADP | ||||||||||||
No | 2.03 (<0.0001) | — | — | — | — | 1.98 (<0.001) | 1.50 (<0.001) | 1.51 (<0.001) | 1.30 (0.03) | 1.47 (<0.001) | 1.36 (0.002) | 1.39 (0.001) |
Sex | 2.05 (<0.0001) | — | — | — | — | 2.01 (<0.001) | 1.50 (<0.001) | 1.52 (<0.001) | 1.37 (0.01) | 1.29 (0.001) | 1.39 (0.001) | 1.36 (0.001) |
Data are HR (P value). The basic models for progression for every stage derived from Cox proportional hazards models were used. The full description of the model-building process is provided in the research design and methods. No, models without any adjustments; PM, progression model; Sex, models adjusted for sex; TG, triglyceride; WHR, waist-to-hip ratio.