Table 1—

Proportion of HLA-DRB1 genotypes according to year of diagnosis of type 1 diabetes

HLA-DRB1 genotypeYear of diagnosis
P*
1950–19691970–19791980–19891990–19992000–2005
DR3,415 (79)35 (60)42 (47)98 (37)8 (28)<0.0001
DR4,40 (0)5 (9)4 (4)31 (12)4 (14)0.039
DR3,30 (0)7 (12)7 (8)19 (7)2 (7)0.800
DR4,X2 (10)8 (14)28 (31)68 (25)10 (34)0.034
DR3,X2 (10)1 (2)7 (8)42 (16)4 (14)0.009
DRX,X0 (0)2 (3)1 (1)9 (3)1 (3)0.950
  • Data are n (%).

  • * P value is for trend across decades.