Table 2—

Incident cases of type 1 diabetes by HLA DRB1 genotype

1985
2002
Incidence 11.3/100,000 person-years*Incidence 23.2/100,000 person-years
DRB1 genotypeProportionCasesProportionCases
DR3,447%5.328%6.5
DR3,3 and DR4,412%1.421%4.9
DR3,X and DR4,X39%4.448%11.1
DRX,X1%0.13%0.7
  • * Based on ref. 14.

  • Calculated as incidence times proportion DRB1 genotype.

  • Where X is non-3 or non-4 DRB1 allele.