Table 1—

Characteristics of study participants aged 50–89 years and the 10-, 20-, and 30-year risk of CVD by diabetes status

Nondiabetic
Diabetic
Nondiabetic
Diabetic
WomenMen
Baseline characteristics and follow-up information
    Original cohort
        Normal weight1225 (48.0)73 (33.2)694 (35.6)35 (17.5)
        Overweight880 (34.5)69 (31.4)998 (51.3)113 (56.5)
        Obese448 (17.6)78 (35.5)256 (13.1)52 (26.0)
        New CVD events14241591267146
        Person-years follow-up637652778396852248
    Offspring
        Normal weight931 (49.6)40 (19.8)399 (24.5)39 (15.2)
        Overweight593 (31.6)63 (31.2)858 (52.6)121 (47.3)
        Obese353 (18.8)99 (49.0)373 (22.9)96 (37.5)
        New CVD events24452387102
        Person-years follow-up282292027234082573
Lifetime risk CVD*
    Original cohort
        10-year6.9 (5.8–7.9)21.6 (9.5–33.6)15.0 (13.3–16.8)28.2 (15.4–41.1)
        20-year21.7 (20.1–23.4)50.0 (39.2–60.9)36.0 (33.8–38.2)57.7 (47.7–67.7)
        30-year38.0 (36.1–39.9)67.1 (58.3–76.0)54.8 (52.5–57.0)78.0 (71.5–84.4)
    Offspring
        10-year3.9 (3.0–4.9)15.9 (7.2–24.6)8.7 (7.1–10.2)13.3 (7.1–19.5)
        20-year11.0 (9.2–12.7)29.3 (19.8–38.7)23.7 (21.3–26.2)43.8 (36.1–51.6)
        30-year26.0 (22.6–29.4)48.6 (38.5–58.7)37.8 (34.3–41.3)61.6 (53.9–69.3)
Lifetime risk of CVD stratified by BMI category*
    10-year
        Normal weight6.2 (4.7–7.6)9.4 (0.0–22.1)11.9 (9.3–14.5)33.2 (6.3–60.0)
        Overweight6.8 (5.0–8.6)16.5 (0.0–34.1)15.1 (12.7–17.5)21.5 (5.9–37.0)
        Obese9.3 (6.3–12.3)41.9 (14.2–69.6)22.8 (17.0–28.5)47.6 (12.1–83.2)
    20-year
        Normal weight18.8 (16.6–21.1)33.7 (16.2–51.2)30.9 (27.4–34.4)54.0 (30.1–77.9)
        Overweight21.6 (18.9–24.4)52.2 (34.6–69.9)37.3 (34.2–40.3)57.9 (45.4–70.4)
        Obese30.0 (25.6–34.3)65.6 (47.1–84.1)44.4 (37.9–50.8)65.4 (40.2–90.6)
    30-year
        Normal weight34.3 (31.6–37.0)54.8 (39.0–70.5)49.2 (45.4–52.9)78.6 (63.7–93.4)
        Overweight38.7 (35.5–41.9)69.3 (55.9–82.7)55.5 (52.4–58.6)74.0 (64.8–83.3)
        Obese46.7 (42.1–51.4)78.8 (66.4–91.2)66.8 (60.7–73.0)86.9 (75.8–97.9)
  • Data aren, n (%), and odds ratio (95% CI).

  • * Expressed as percent developing CVD, adjusted for the competing risk of death. For original cohort and offspring among participants aged 50–89 years, 95% CIs are stratified by BMI category for the offspring cohort only.

  • In the original cohort, 0.08% of participants were lost to follow-up, and in the offspring cohort, 0.5% of participants were lost to follow-up. In the original cohort, 10.3% of CVD events were fatal and in the offspring cohort, 5.4% were fatal.