Table 1—

Clinical characteristics of young subjects with type 1 diabetes with and without abnormal PFT

Normal PFTAbnormal PFTTotalP value
n172159331
Age (years)15.7 (13.5–17.3)15.1 (13.5–17.3)15.4 (13.5–17.3)0.46
Sex (male/female)62/110100/59172/159<0.001
Diabetes duration (years)7.6 (5.0–10.3)7.9 (4.3–11.0)7.6 (4.9–10.6)0.77
A1C (%)8.6 ± 1.38.5 ± 1.18.6 ± 1.30.69
Total cholesterol (mmol/l)4.3 (3.9–5.0)4.3 (3.8–4.8)4.3 (3.8–4.9)0.42
SBP (percentile)54 (27–82)71 (38–85)59 (32–82)0.004
DBP (percentile)73 (48–83)73 (48–87)73 (48–84)0.49
BMI (percentile)74 (56–87)78 (63–91)76 (61–88)0.02
PON1 activity*
    Paraoxon (units/ml)39.6 (28.3–79.3)45.4 (28.1–85.4)41.4 (28.4–79.9)0.41
    Phenylacetate (units/ml)64.9 (44.6–81.6)70.6 (56.7–80.4)66.7 (52.8–80.5)0.26
  • Data are means ± SD or median (interquartile range).

  • * PON1 activity was measured in 144 subjects.