Table 2—

Allele frequencies and enzyme activity of PON1 genotypes for hydrolysis of paraoxon and phenylacetate as substrates

PolymorphismGenotype (n)Frequency (Hardy-Weinberg)Paraoxon (units/ml)Phenylacetate (units/ml)
n331144144
p.Leu53MetLL (135)0.40 (0.39)77.8 (46.2–106.5)73.4 (64.9–87.7)
ML (149)0.45 (0.46)39.1 (28.4–64.7)66.2 (53.0–80.9)
MM (47)0.14 (0.13)21.0 (16.7–30.4)56.0 (39.5–63.0)
    P value<0.001<0.001
p.Gln191ArgRR (29)0.09 (0.08)99.8 (73.0–185.0)68.2 (32.2–85.8)
RQ (127)0.38 (0.39)80.3 (63.4–106.1)68.7 (54.6–80.1)
QQ (175)0.53 (0.52)30.5 (24.5–39.8)66.7 (53.1–81.7)
    P value<0.0010.81
c.-107C>T*CC (90)0.27 (0.26)61.4 (37.9–90.3)77.4 (68.4–90.2)
CT (154)0.49 (0.49)40.3 (28.7–82.3)70.3 (59.4–81.6)
TT (75)0.24 (0.24)34.6 (20.8–73.6)54.0 (39.7–63.2)
    P value0.017<0.001
  • Data are median (interquartile range) unless otherwise indicated.

  • * For c.-107C>T, genotyping was performed in 319 individuals and PON1 activity measured in 139 subjects.