Table 3—

Hormonal values and glycemic control by age-group in type 1 diabetic young women and nondiabetic control subjects

Age <20 years
Age ≥20 years
ControlType 1 diabeticPControlType 1 diabeticP
n36374926
Unadjusted data
    IGF-1 (ng/ml)*
        Baseline308 ± 67.4280 ± 81.80.121222 ± 89.6209 ± 64.60.512
        Follow-up288 ± 78.1213 ± 83.4<0.001166 ± 48.7147 ± 41.10.097
        Percent change−3.5 ± 30.2−20.9 ± 27.20.013−20.4 ± 21.2−25.7 ± 25.70.345
    IGFBP-3 (mg/ml)*
        Baseline3.2 ± 0.513.0 ± 0.600.2342.9 ± 0.782.8 ± 0.720.527
        Follow-up3.3 ± 0.913.1 ± 0.730.2322.9 ± 0.752.6 ± 0.650.043
        Percent change−3.7 ± 13.33.4 ± 20.90.1824.0 ± 29.8−6.1 ± 21.10.129
    Osteocalcin (ng/ml)*
        Baseline18.9 ± 8.319.3 ± 8.80.82910.4 ± 5.89.7 ± 5.20.615
        Follow-up12.6 ± 6.710.3 ± 4.60.0977.7 ± 2.96.7 ± 3.30.155
        Percent change−22.9 ± 52.9−34.4 ± 44.10.317−4.3 ± 56.2−22.8 ± 35.30.138
    N-telopeptides/creatinine (nmol/l BCE/mmol/l creatinine)*
        Baseline76.9 ± 35.980.3 ± 49.40.73732.2 ± 12.734.0 ± 18.10.614
        Follow-up58.1 ± 28.347.9 ± 23.70.09934.1 ± 17.532.0 ± 13.80.604
        Percent change−20.7 ± 28.9−26.3 ± 40.30.50324.0 ± 91.37.0 ± 47.10.378
Adjusted data
    IGF-1 (ng/ml)
        Baseline310 ± 67.4279 ± 81.80.090217 ± 89.6218 ± 64.60.942
        Follow-up284 ± 78.1216 ± 83.40.001161 ± 48.7155 ± 41.10.558
        Percent change−5.1 ± 30.2−19.3 ± 27.20.043−20.2 ± 21.2−26.0 ± 25.70.347
    IGFBP-3 (mg/ml)
        Baseline3.2 ± 0.513.0 ± 0.600.2582.8 ± 0.783.0 ± 0.720.525
        Follow-up3.3 ± 0.913.1 ± 0.730.4342.9 ± 0.752.6 ± 0.650.127
        Percent change−4.3 ± 13.34.0 ± 20.90.1195.3 ± 29.8−8.4 ± 21.10.051
    Osteocalcin (ng/ml)
        Baseline18.0 ± 8.320.3 ± 8.80.18710.1 ± 5.810.2 ± 5.20.952
        Follow-up12.2 ± 6.710.6 ± 4.60.2218.0 ± 2.96.3 ± 3.30.038
        Percent change−20.9 ± 52.9−36.4 ± 44.10.1880.24 ± 56.2−30.9 ± 35.30.023
    N-telopeptides/creatinine (nmol/l BCE/mmol/l creatinine)
        Baseline74.4 ± 35.982.9 ± 49.40.33132.0 ± 12.734.5 ± 18.10.523
        Follow-up57.4 ± 28.348.6 ± 23.70.13034.5 ± 17.531.1 ± 13.80.436
        Percent change−18.4 ± 28.9−28.7 ± 40.30.21426.8 ± 91.31.7 ± 47.10.238
    A1C (%)
        Baseline8.2 ± 1.27.4 ± 0.90.008
        Follow-up8.5 ± 1.57.6 ± 0.90.007
        Percent change4.3 ± 16.03.5 ± 12.30.833
  • Data are means ± SD. Lab values were calculated in the cohort aged <20 years for IGF-1, telopeptides/creatinine, and A1C (case subjects, n = 36); IGFBP-3 (control subjects, n = 23; case subjects, n = 22); and osteocalcin (case subjects, n = 36); and in the cohort aged ≥20 years for osteocalcin (control subjects, n = 46; case subjects, n = 25).

  • * P values by Student's t test.

  • P values by ANCOVA, adjusted for age and BMI.

  • P values by Student's t test in case subjects between age-groups. BCE, bone collagen equivalent.