Table 1—

Characteristics of patients at baseline stratified by development of diabetes

ParameterAll patientsDid not develop diabetesIncident diabetesP value
n3,2752,898377
Age (years)14.1 (9.2–21.1)13.5 (8.9–20.5)18.0 (12.4–25.4)<0.0001
Sex (female)1,491 (45.5)1,288 (44.4)203 (53.8)<0.001
Ethnicity (white)3,166 (96.7)2,797 (96.5)369 (97.9)NS
BMI (kg/m2)18.6 (16.4–21.3)18.5 (16.3–21.3)19.2 (17.3–21.4)<0.001
BMI z score−0.15 (−0.86 to 0.56)−0.10 (−0.81 to 0.59)−0.49 (−1.23 to 0.22)<0.0001
FEV1 (% predicted)72.9 (53.0–91.3)75.3 (55.3–92.7)57.8 (36.9–74.5)<0.0001
Forced vital capacity (% predicted)82.6 (68.0–94.1)83.6 (69.6–95.3)73.3 (57.1–86.9)<0.0001
Any use of pancreatic enzyme2,941 (89.8)2,579 (89.0)362 (96.0)<0.01
Lipase dose (units/day)250,000 (150,000–400,000)250,000 (150,000–400,000)300,000 (184,000–500,000)<0.0001
Lipase dose (units · kg body weight−1 · day−1)6,829 (3,464–10,200)6,828 (3,448–10,150)6,865 (3,602–10,560)NS
Supplemental feeding1,439 (43.9)1,236 (42.7)203 (53.8)<0.0001
Oral corticosteroids313 (9.6)263 (9.1)50 (13.3)0.012
Any corticosteroids use1,761 (53.8)1,526 (52.7)235 (62.3)<0.001
Former organ transplantation44 (1.3)37 (1.3)7 (1.9)NS
Abnormal liver function tests406 (12.4)342 (11.8)64 (16.9)<0.01
Use of ursodeoxycholic acid or taurine534 (16.3)455 (15.7)79 (21.0)0.012
Any hepatic dysfunction719 (28.1)610 (21.0)109 (28.9)<0.001
P. aeruginosa1,925 (58.8)1,651 (57.0)274 (72.7)<0.0001
B. cepacia151 (4.6)129 (4.5)22 (5.8)NS
S. aureus1,379 (42.1)1,223 (42.2)156 (41.4)NS
H. influenzae668 (20.4)605 (20.9)63 (16.7)NS
A. fumigatus341 (10.2)301 (10.2)40 (10.6)NS
Methicillin-resistant S. aureus46 (1.4)40 (1.4)6 (1.6)NS
ABPA197 (6.0)178 (6.1)19 (5.0)NS
CFTR mutation class<0.01
    I266 (8.1)227 (7.8)39 (10.3)
    II2,608 (79.6)2,299 (79.3)309 (82.0)
    III256 (78.2)231 (8.0)25 (6.6)
    IV125 (3.8)121(4.2)4 (1.1)
    V20 (0.6)20 (0.7)0 (0)
    Unknown0 (0)0 (0)0 (0)
CFTR mutation class I or II2,874 (87.7)2,526 (87.2)348 (92.3)<0.01
Age at diagnosis of cystic fibrosis (years)0.4 (0.08–2.5)0.4 (0.08–2.5)0.5 (0.08–2.0)NS
Cystic fibrosis detected by screening377 (11.5)349 (12.0)28 (7.4)0.011
  • Data are absolute values (medians) or n (%) for continuous variables with interquartile range and percentages for categorical variables. P values represent difference between groups using Kruskal-Wallis tests for continuous variables and χ2 tests for categorical variables.