Anthropometric and biochemical characteristics of study subjects
| Study subjects | Age- and sex-adjusted correlations between plasma IGF-1 levels and cardiometabolic variables | Age- and sex-adjusted correlations between plasma IL-6 levels and cardiometabolic variables | |||||
|---|---|---|---|---|---|---|---|
| Pearson's correlation coefficient (r) | P | Pearson's correlation coefficient (r) | P | ||||
| Sex (M/F) | 80/106 | — | — | — | — | ||
| Age (years) | 41 ± 14 | −0.53* | 0.0001 | 0.30* | 0.0001 | ||
| BMI (kg/m2) | 30.1 ± 8.4 | −0.28 | 0.0001 | 0.33 | 0.0001 | ||
| Waist circumference (cm) | 97 ± 16 | −0.29 | 0.0001 | 0.35 | 0.0001 | ||
| SBP (mmHg) | 127 ± 19 | −0.15 | 0.04 | 0.15 | 0.04 | ||
| DBP (mmHg) | 80 ± 11 | −0.10 | 0.18 | 0.13 | 0.08 | ||
| Total Cholesterol (mg/dl) | 198 ± 41 | 0.03 | 0.66 | −0.006 | 0.95 | ||
| HDL Cholesterol (mg/dl) | 54 ± 14 | 0.11 | 0.11 | −0.07 | 0.33 | ||
| Triglyceride (mg/dl) | 121 ± 69 | −0.19 | 0.01 | 0.10 | 0.15 | ||
| Fasting Glucose (mgl/dl) | 90 ± 14 | 0.03 | 0.63 | −0.007 | 0.93 | ||
| 2-h glucose (mg/dl) | 117 ± 39 | −0.07 | 0.42 | 0.13 | 0.11 | ||
| Fasting Insulin (μU/ml) | 12 ± 7 | −0.16 | 0.03 | 0.28 | 0.0001 | ||
| IGF-1 (ng/ml) | 191 ± 90 | — | — | −0.15 | 0.04 | ||
| IL-6 (pg/ml) | 2.5 ± 2.2 | −0.15 | 0.04 | — | — | ||
| HOMA | 2.7 ± 1.8 | −0.21 | 0.004 | 0.22 | 0.002 | ||
| WBGD (mg · kg−1 · min−1) | 7.6 ± 3.2 | 0.29 | 0.002 | −0.35 | 0.0001 | ||
| AHA-NHLB–defined metabolic syndrome (yes/no) | 60/126 (32.3) | — | — | — | — | ||
| High waist circumference (≥102 cm for men and ≥88 cm for women) (yes/no) | 91/95 (48.9) | — | — | — | — | ||
| High fasting glucose (≥100 mg/dl) (yes/no) | 47/139 (25.3) | — | — | — | — | ||
| High triglyceride (≥150 mg/dl l) (yes/no) | 50/136 (26.8) | — | — | — | — | ||
| Low HDL (<40 mg/dl in men or <50 mg/dl in women) (yes/no) | 54/132 (29.0) | — | — | — | — | ||
| High blood pressure (SBP ≥130 mmHg or DBP ≥85 mmHg) (yes/no) | 101/85 (54.6) | — | — | — | — | ||
Data are means ± SD and n (%). Fasting plasma insulin, triglycerides, and IL-6 levels were log transformed for statistical analysis, but values in the table represent a back transformation to the original scale. DBP, diastolic blood pressure; SBP, systolic blood pressure.
↵* Adjusted for sex.