Table 2—

Hyperglycemic clamp data in the three groups

NGTIGTType 2 diabetesANOVA
n121917P
First-phase insulin (pmol/l)2,376.0 ± 1,729.9a,b1,182.0 ± 625.2708.0 ± 938.40.001
First-phase C-peptide (nmol/l)4.3 ± 2.0b3.0 ± 1.02.2 ± 1.40.001
Second-phase insulin (pmol/l)2,563.2 ± 1,363.2b1,902.6 ± 1,336.2982.2 ± 797.00.003
Second-phase C-peptide (nmol/l)5.0 ± 1.5b4.7 ± 1.9c3.0 ± 1.10.002
  • Data are means ± SD unless otherwise indicated. C-peptide levels were not available in 3 subjects with IGT. Superscripts are ANOVA P values for post-hoc analysis (Bonferroni correction):

  • a , P < 0.05 in NGT vs. IGT;

  • b , P < 0.05 in NGT vs. type 2 diabetes;

  • c : P < 0.05 in IGT vs. type 2 diabetes.