Table 3

Longitudinal changes in thigh muscle CSA (cm2) by baseline diabetes status in the Health ABC Study, stratified by sex

Without diabetesUndiagnosed diabetesDiagnosed diabetesP
n1,290125214
Men
    Model 1−13.0 ± 0.8−17.6 ± 2.2−14.0 ± 1.70.153
    Model 2−13.3 ± 0.7−17.0 ± 2.2−13.1 ± 1.70.282
    Model 3−13.4 ± 0.6−15.2 ± 1.7−13.4 ± 1.30.632
    Model 4−13.6 ± 0.6−15.9 ± 1.9−12.8 ± 1.40.411
Women
    Model 1−5.1 ± 0.5−11.7 ± 1.8*−11.1 ± 1.4*<0.001
    Model 2−5.2 ± 0.5−11.3 ± 1.8*−10.6 ± 1.4*<0.001
    Model 3−5.3 ± 0.4−10.8 ± 1.4*−10.0 ± 1.1*<0.001
    Model 4−5.2 ± 0.4−10.6 ± 1.5*−9.3 ± 1.2*<0.001
  • Data are adjusted means ± SE. Model 1: adjusted for age, race, and clinic site; model 2: additionally adjusted for baseline body weight; model 3: additionally adjusted for changes in body weight; and model 4: additionally adjusted for IL-6 and TNF-α.

  • *P < 0.01 vs. those without diabetes after Bonferroni correction for multiple comparisons.