Table 2—

Comparison of pregnancy outcomes in studies of pregnant type 1 diabetic women with microalbuminuria covering the same geographical area in Eastern Denmark

Ekbom et al., 2001 (3)Nielsen et al., 2006 (5)Current study
Antihypertensive therapy strategyPreeclampsia Diastolic BP >95 mmHgBP >140/90 mmHg UAE >2 g/24 h ACE inhibitor before pregnancyBP >135/85 mmHg UAE ≥300 mg/24 h ACE inhibitor before pregnancy
n262010
Duration of diabetes (years)19 ± 518 ± 815 ± 10
A1C at inclusion (%)8.1 ± 0.96.8 ± 0.57.3 ± 1.5
Antihypertensive therapy (week of onset)29 (20–34)13 (before to 34)Before (before to 14)
Patients on antihypertensive therapy during pregnancy (n)9 (35)10 (50)5 (50)
ACE inhibitor before pregnancy (n)5 (19)9 (45)4 (40)
Systolic BP at inclusion (mmHg)121 ± 13121 ± 14117 ± 14
Diastolic BP at inclusion (mmHg)71 ± 873 ± 874 ± 8
UAE (mg/24 h)69 (16–278)74 (30–287)91 (30–198)
Preeclampsia (n)11 (42)4 (20)0
Gestational age at delivery (days)250 (182–270)259 (244–271)264 (252–272)
Preterm delivery before 34 weeks (n)6 (23)00
Preterm delivery before 37 weeks (n)16 (62)8 (40)2 (20)
Birth weight (g)3,124 ± 7673,279 ± 6633,471 ± 670
Perinatal mortality (n)1 (4)00
Major congenital malformations (n)1 (4)00
  • Data are means ± SD, medians (range), or n (%). BP, blood pressure. Duration of diabetes, A1C, BP, and birth weight in the current study are given as means ± SD to compare results with previous studies from our center (3,5).