Table 1

Fasting plasma glucose and glucagon concentrations in patients with type 1 diabetes and nondiabetic individuals sampled at the screening visit and at 0 min in the mixed meal and glimepiride studies after intravenous insulin infusion to maintain near-euglycemia overnight in the patients with type 1 diabetes

Type 1 diabetesNondiabetic
n2420
Plasma glucose (mmol/l)
    Screening7.7 ± 0.74.7 ± 0.1
    Mixed-meal study5.6 ± 0.24.9 ± 0.1
    Glimepiride study6.0 ± 0.24.9 ± 0.1
Plasma glucagon (pmol/l)
    Screening27 ± 127 ± 1
    Mixed-meal study22 ± 1*27 ± 1
    Glimepiride study24 ± 128 ± 1
  • Data are means ± SEM. To convert glucose to mg/dl divide by 0.05551, glucagon to pg/ml divide by 0.2871.

  • *P = 0.0007.

  • P = 0.0278.