Table 3—

Comparison of pharmacodynamic parameters between day 1 and day 4

Pharmacodynamic parametersAll Subjects
P
Day 1Day 4Difference (95%CI)
AUCGIR (mg/kg)948 ± 98847 ± 82101 (−151 to 353)0.42
GIRmax (mg/kg/min)6.8 ± 0.67.5 ± 0.7−0.69 (−2.49 to 1.12)0.39
TmaxGIR (min)97 ± 779 ± 518 (0.38 to 35)0.03
Time to discontinuation of exogenous glucose (min)254 ± 9211 ± 1243 (12 to 74)0.004
Ti50 (min)51 ± 438 ± 313 (4 to 22)0.004
Td50 (min)195 ± 8153 ± 942 (18 to 66)0.0004
  • Data are means ± SE.