Comparison of pharmacodynamic parameters between day 1 and day 4
| Pharmacodynamic parameters | All Subjects | P | ||||
|---|---|---|---|---|---|---|
| Day 1 | Day 4 | Difference (95%CI) | ||||
| AUCGIR (mg/kg) | 948 ± 98 | 847 ± 82 | 101 (−151 to 353) | 0.42 | ||
| GIRmax (mg/kg/min) | 6.8 ± 0.6 | 7.5 ± 0.7 | −0.69 (−2.49 to 1.12) | 0.39 | ||
| TmaxGIR (min) | 97 ± 7 | 79 ± 5 | 18 (0.38 to 35) | 0.03 | ||
| Time to discontinuation of exogenous glucose (min) | 254 ± 9 | 211 ± 12 | 43 (12 to 74) | 0.004 | ||
| Ti50 (min) | 51 ± 4 | 38 ± 3 | 13 (4 to 22) | 0.004 | ||
| Td50 (min) | 195 ± 8 | 153 ± 9 | 42 (18 to 66) | 0.0004 | ||
Data are means ± SE.