Table 1—

Treatment targets for variables and percent decrease in incidence of MIs as a result of normalizing variable values to reach treatment targets

Target for normalizationDecrease in incidence of MIs (fatal and nonfatal)
Insulin resistanceAverage value at ages 20–30 years42
SBP (mmHg)11436
HDL cholesterol (mg/dl)46 (men), 54 (women)31
BMI (kg/m2)22.521
LDL cholesterol (mg/dl)10816
Triglycerides (mg/dl)10810
FPG (mg/dl)869
SmokingNever smoke9
Family historyNo family history4
Causality not established
    FFA (mg/dl)2018
    C-reactive protein (mg/dl)0.3210
    ApoB (mg/dl)859
    Lipoprotein(a) (mg/dl)57 (blacks), 21.5 (nonblacks)9
    Homocysteine (μmol/l)7.05
All variablesNA94
  • Data for decrease in myocardial infarction are percent. Treatment targets represent the average values for people aged 20–30 years in the U.S. population. NA, not applicable.