Table 2

Mean differences in change in cognitive function scores, by tertile of dietary fat intake since midlife

Tertile 1Tertile 2Tertile 3Ptrend
Saturated fat (median intake)*9.811.513.5
Global score0.00 (ref)−0.006 (−0.09 to 0.08)−0.12 (−0.22 to −0.01)0.02
Verbal score0.00 (ref)−0.02 (−0.12 to 0.09)−0.09 (−0.22 to 0.05)0.2
Monounsaturated fat (median intake)*10.612.614.6
Global score0.00 (ref)0.10 (0.01 to 0.19)0.12 (−0.002 to 0.24)0.06
Verbal score0.00 (ref)0.06 (−0.05 to 0.17)0.08 (−0.07 to 0.23)0.3
Polyunsaturated fat (median intake)*4.75.66.7
Global score0.00 (ref)0.03 (−0.04 to 0.11)0.03 (−0.06 to 0.11)0.5
Verbal score0.00 (ref)0.02 (−0.08 to 0.11)0.02 (−0.09 to 0.13)0.7
Trans fat (median intake)*1.21.62.0
Global score0.00 (ref)−0.09 (−0.17 to −0.01)−0.15 (−0.24 to −0.06)0.002
Verbal score0.00 (ref)−0.10 (−0.20 to 0.0002)−0.15 (−0.27 to −0.03)0.01
Ratio of polyunsaturated to saturated fat (median intake)0.40.50.6
Global score0.00 (ref)0.04 (−0.03 to 0.11)0.08 (0.008 to 0.16)0.03
Verbal score0.00 (ref)0.04 (−0.05 to 0.14)0.07 (−0.03 to 0.16)0.2
  • Data are mean differences (95% CI) unless otherwise indicated. Average diet intake since midlife from 1980 through the initial cognitive interview. Models are adjusted for age (continuous), education (registered nurse, bachelor's, or graduate degree), other fats and cholesterol (in tertiles), total caloric intake (continuous), baseline cognition (continuous), time between cognitive interviews (continuous), BMI (continuous), physical activity (continuous), diabetes medication (none, oral hypoglycemic medication only, insulin use), and duration of diabetes (<5, 5–9, 10–14, and ≥15 years).

  • *Fat intake is expressed as a percentage of total energy consumption.